5. Conclusion

Cisplatin and its metabolites can bind to DNA, causing damage that may result in chromosome breaks, micronucleus formation and cell death. Administration of Xancus pyrum extract in cisplatin treated mice, found to enhance the bone marrow cellularity and α-esterase positive cells, which were drastically reduced in cisplatin alone treated control animals suggests that cisplatin induced myelosuppression was reversed or inhibited by Xancus pyrum extract administration possibly through its chemoprotective activity.
