*3.1.1.1 Halocin S8 (HalS8)*

HalS8 is the first characterized microhalocin with 36 amino acids (3580 Da), it is synthesized by the uncharacterized S8a haloarchaea [29]. Halocin S8 showed a narrow inhibitory spectrum and can only inhibit *Halobacterium salinarum* NRC817, *Halobacterium* GRB and *Haloferax gibbonsii* [29]. It can be desalted and it is heat resistant. Its activity is resistant to trypsin but sensitive to proteinase K and is undetectable in the transition to the stationary phase [29, 30]. The *halS8 gene* is *encoded* on a ∼200-kbp megaplasmid [29].
