*3.1.1.2 Halocin HalR1 (HalR1)*

Halocin R1, the second characterized microhalocin, is produced by *Halobacterium salinarum* GN101, a strain isolated from solar salt marsh in Mexico [31]. Initially HalR1 was described with a molecular weight of 6.2 kDa [32] and later on, it was shown that the HalR1 peptide is composed of 38 amino acids [24, 29]. Like HalS8, the activity is not affected by desalting and is resistant to acids, bases, organic solvents DNase and RNase, and against some proteases such as papain, trypsin or thermolysin, but it is sensitive to proteinase K, pronase P and elastase [20, 32].
