We are IntechOpen, the world's leading publisher of Open Access books Built by scientists, for scientists

4,800+

Open access books available

123,000+

140M+

International authors and editors

Downloads

Our authors are among the

Top 1% most cited scientists

12.2%

Contributors from top 500 universities

Selection of our books indexed in the Book Citation Index in Web of Science™ Core Collection (BKCI)

## Interested in publishing with us? Contact book.department@intechopen.com

Numbers displayed above are based on latest data collected. For more information visit www.intechopen.com

## Meet the editors

Dr. B.P. Nandeshwarappa holds an M.Sc. and Ph.D. from Kuvempu University, Karnataka, India. He was a Postdoctoral fellow at the Institute of Fine Chemicals, East China University of Science and Technology, Shanghai. His research has been largely in organic chemistry. He has published many scientific papers in reputed journals. He has presented his research papers at national and international conferences, seminars, and workshops. He has

edited five books, authored seven specialized books, and five book chapters. He has guided fifty-one dissertation/project theses for postgraduates and is currently guiding four Ph.D. scholars. He has fourteen years of teaching experience and nearly three years of industry experience. He is currently working as an Associate Professor at the Department of Studies in Chemistry, Davangere University, Davangere.

Dr. Sadashiv S. O. is presently an Assistant Professor in the Department of Food Technology, Davangere University, Davanagere, Karnataka. He completed his M.Phil and Ph. D. in microbiology from Karnataka University, Dharwad, Karnataka, India. He has published various research articles in national and international peer-reviewed journals and written six book chapters, two books/monographs, and edited four books. He has secured the

Young Scientists Award twice, one Gold Medal award for the research contributions in the field of Veterinary Microbiology from various academic organizations, and also received an Appreciation Award from the Zoological Society of India (ZSI). He has participated and presented research papers in many conferences/seminars/ workshops/training sessions at national and international levels. His main areas of research are veterinary microbiology, dairy microbiology, environmental microbiology, and food technology.

Contents

**Section 1**

**Preface III**

Synthetic Section **1**

**Chapter 1 3**

**Chapter 2 9**

**Chapter 3 27**

**Chapter 4 39**

**Chapter 5 57**

**Chapter 6 79**

**Chapter 7 91**

One-Pot-Condensation Reaction of Heterocyclic Amine, 1,3-Diketone and Aldehydes Using *In Situ* Generated Superoxide Ion: A Rapid Synthesis of Structurally Diverse Drug-Like Complex Heterocycles

Introductory Chapter: Synthesis and Antimicrobial Activities

Phenacyl Bromide: An Organic Intermediate for Synthesis

Amidoxime Derivatives with Local Anesthetic, Antitubercular,

*by Lyudmila Kayukova, Umirzak Jussipbekov and Kaldybay Praliyev*

Recent Developments of Target-Based Benzimidazole Derivatives

*by Nerella Sridhar Goud, Pardeep Kumar and Rose Dawn Bharath*

Thiazole Moiety: An Interesting Scaffold for Developing New

*by Sandra Ramos-Inza, Carlos Aydillo, Carmen Sanmartín* 

The Oxygen-Containing Fused Heterocyclic Compounds

*by Hillemane Venkatachalam and Nanjangud Venkatesh Anil Kumar*

of Dihydroazeto[2′,3′:4,5]seleno[2,3-*b*]quinolines *by B.P. Nandeshwarappa, G.K. Prakash and S.O. Sadashiv*

of Five- and Six-Membered Bioactive Heterocycles

*by Dinesh Kumar Jangid and Surbhi Dhadda*

and Antidiabetic Activity

as Potential Anticancer Agents

Antitumoral Compounds

*by Sundaram Singh and Savita Kumari*

*and Daniel Plano*

## Contents



Preface

Heterocyclic systems are important building blocks for new materials possessing interesting electronic, mechanical, or biological properties. For more than a century, many heterocycles have constituted the largest areas of research in organic chemistry. Heterocycles play an important role in biochemical processes because the side groups of the most typical and essential constituents of living cells, DNA and RNA, are based on aromatic heterocycles. The presence of heteroatoms results in significant changes in the cyclic molecular structure due to the availability of unshared pairs of electrons

and the difference in electronegativity between heteroatoms and carbon.

Many synthetic methods have been developed for the preparation of heterocycles. The current book project covers the basics and advanced utility of heterocycles in biochemistry, industrial chemistry, environmental sciences, pharmacy, microbiology, biotechnology, and related disciplines. Also, it will fulfill the requirement for new approaches in experimental skills and solving problems obtained during functional group transformation. This book provides a broad range of solutions to the problems of graded difficulties from organic reactions, rearrangements, and reagents along with their isolation and synthetic applications. The main goal of this book is to build on the foundation of synthesis and characterization. Special emphasis has been placed on the synthesis and mechanism of the reactions of different classes of heterocycles. Furthermore, it will bridge the gap between teaching, research, and practice. Finally, this book project provides a concise and comprehensive overview of

the methods and biological importance of heterocyclic compounds synthesis.

**B.P. Nandeshwarappa** Davangere University,

Garden City University,

India

India

**Sadashiv S.O.**
