**Acknowledgements**

The study was supported by the T. & L. de "Beaumont Bonelli Foundation for cancer research" (to AR). We are thankful to Dr. Stephen Duckworth for his support in editing of the manuscript, the Committee on Biotechnologies and VirusSphere, World Academy of Biomedical Technologies, UNESCO, Paris, France (to GT), and Thomas More University U.P.T.M., Rome, Italy (to GT).
