**Acknowledgements**

The authors acknowledge the financial supports from the Xiangya Hospital Funds for Talent Introduction (to X.Z.), the Hunan Provincial "Hundred Talent Plan" program (to X.Z.), the Hunan Provincial Natural Science Foundation of China (Grant No. 14JJ7008 to X.Z.), China "863" Plan Project (Grant No. 2014AA020610-1 to X.Z.), and the National Natural Science Foundation of China (Grant Nos. 81572278 and 81272798 to X.Z.).
