Meet the editors

Dr. Alba Scerrati was born in Rome, where she lived until 2017. She then moved to Ferrara. She graduated from medical school in 2010 and completed her neurosurgical residency (in 2017) in the Catholic University of Rome, Policlinico Gemelli. She is Assistant Professor of Neurosurgery at the University of Ferrara where she also works as a neurosurgeon. Dr. Scerrati's main scientific interests are in skull base surgery and neurovascular

surgery. She is currently working on the development of 3D printing techniques for neurovascular surgery training and simulation. She is the author and co-author of more than 30 indexed publications (https://www.ncbi.nlm.nih.gov/pubmed/?term=scerrati+a).

Prof. Pasquale De Bonis has been Associate Professor of Neurosurgery at the University of Ferrara and Head of the Neurosurgery Residency Program since 2017. He graduated cum laude in 2004 from the Medical School at the Catholic University of Rome, Policlinico Gemelli. He completed his residency in neurosurgery in 2009 and his PhD in Neurosciences in 2012 at the Catholic University of Rome. Prof. De Bonis's main scientific

interests are in neuroncology, CSF dynamics, and spinal diseases. He is the author and co-author of more than 150 indexed publications (https://www.ncbi.nlm.nih. gov/pubmed/?term=de+bonis+p).

Contents

**Section 1**

*by Asifur Rahman*

*by Asifur Rahman*

of Brain Tumors

*and Jason H. Huang*

Ultrasound in Neurosurgery *by Giuseppe Maria Della Pepa*

Immunotherapy for Glioblastomas

**Section 2**

Robotic-Assisted Systems for Spinal Surgery *by Mayank Kaushal, Shekar Kurpad and Hoon Choi*

*by Oriela Rustemi, Alessandro Della Puppa and Alba Scerrati*

Role of Cranioplasty in Management of Chiari Malformation

"Stealth Cranioplasty" for Adult Chiari Malformation Type 1: A Philosophical Journey of Innovation, Adaptation, and Evolution

Oncological, Vascular, and Spinal Uses of Contrast-Enhanced

MR-Guided Laser Interstitial Thermal Therapy for Treatment

*by Alexa Semonche, Evan Luther, Katherine Berry, Ashish Shah, Daniel Eichberg, Long Di, Michael Kader and Michael E. Ivan*

*by Wan-Ming Hu, Frank Y. Shan, Sanjib Mukherjee, Danijela Levacic* 

Perfusion, and Function Monitoring

**Preface III**

Surgery **1**

**Chapter 1 3**

**Chapter 2 23** Innovations in the Surgery of Cerebral Aneurysms: Enhanced Visualization,

**Chapter 3 39**

**Chapter 4 63**

Imaging and Adjuvant Therapies **87**

**Chapter 5 89**

**Chapter 6 107**

**Chapter 7 123**

## Contents


Preface

"There are no constraints on the human mind, no walls around the human spirit, no

technology. From the introduction of the operating microscope to the development of endoscopes or exoscopes; from the CT scan to the new 3T MRI; from standard ultrasounds to modern high-definition navigated ultrasounds; from intraoperative DSA to new indocyanine video-angiography; and from custom bone reconstruction

barriers to our progress except those we ourselves erect." (Ronald Reagan)

The history of neurosurgery is characterized by a strong relationship with

Surgery needs technologies to improve its results and the clinical outcome of patients. New generations of surgeons should be trained in the use of new technologies and be open minded towards what tools biomedical engineering or basic

techniques in neurosurgery and to their application in clinical practice.

Appreciation is due to Prof. Pasquale De Bonis for helping me in this enjoyable task, to Dr. Flavia Dones for her unfailing support and wise counsel, and to

Prof. Michele A. Cavallo for his tireless commitment to making me a better surgeon.

Department of Morphology, Experimental Medicine and Surgery,

**Dr. Alba Scerrati**

Italy

Italy

Professor,

University of Ferrara,

**Pasquale De Bonis**

University of Ferrara,

Department of Neurosurgery,

This book is designed to be a comprehensive introduction to new developments and

to 3D printed skull protheses.

science could offer to improve surgical practice.
