*4.2.1 Benefits of MCC in wet granulation*

Basically, using MCC in wet granulation included wetting MCC with water followed by drying and compression. The process resulted in lower hardness tablets than that with dry compression. The wet granulation reduces the density of agglomerated particles thereby decreasing their internal surface area. In contrast, it can also cause adhesion between particle agglomerates, reducing external surface area resulting in less particle interlocking and hydrogen bonding. In general, using Avicel PH-101 or Avicel PH-102 in wet granulation formulations with concentration between 5 and 20% offers the following benefits [51]:

