**9. Conclusion**

Barriers of HIV/AIDS treatment


Microbubbles-based drug delivery for HIV/AIDS treatment


Microbubble as therapeutic agents


Gene therapy for HIV/AIDS treatment


**111**

*Using Microbubbles as Targeted Drug Delivery to Improve AIDS*

Microbubble used as preventive HIV/AIDS Vaccine

• Microbubbles, loaded with both antigen mRNA as well as immunomodulating Trimix mRNA, which can be used for the ultrasound-triggered transfection of

• DC sonoporation using microbubbles loaded with a combination of antigen and TriMix mRNA can elicit powerful immune responses *in vivo*, and might serve

• New approaches are always being explored for development of an effective

• For delivering DNA various polymer and lipid- based microbubbles have been

• Microbubbles encapsulate antigens in their core and cross link to antigen CD4+ and CD8+ T cells. These absorbing antigen allow B cell to generate responses.

• Microbubble vaccines can be given by different route of administration.

I would like to express my special thanks of gratitude to my Institute Shri Sachhidanand Shikshan Santh's Taywade College of Pharmacy as well as our principal Dr. C. A. Doifode Sir who gave me the golden opportunity to do this wonderful project on the topic Using Microbubble as Target Drug Delivery to Improve Aids and I came to know about so many new things I am really thankful to them. Secondly I would thankful to Mr. Rafik Shaikh and K.E.M. H.R.C. Pune who helped

me a lot in finalizing this project within the limited time frame.

\*Address all correspondence to: harsha\_20054@rediffmail.com

\*, Rafik Yakub Shaikh<sup>2</sup>

1 Shri Sachhidanand Shikshan Santh's Taywade College of Pharmacy, Nagpur, India

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

and Chandrashekhar A. Doifode1

as a potential tool for further *in vivo* DC vaccination applications.

*DOI: http://dx.doi.org/10.5772/intechopen.87157*

Immunotherapy for HIV/AIDS

dendritic cell (DC).

HIV/AIDS vaccine.

used.

**Acknowledgements**

**Author details**

Harsha Virsingh Sonaye1

2 K.E.M. Hospital Research Centre, Pune, India

provided the original work is properly cited.
