Meet the editor

Dr. Emad Hamdy Gad is Associate Professor of Surgery in the Department of Hepatobiliary Surgery, National Liver Institute, Menoufia University, Egypt. He obtained an MD in Hepatobiliary and Liver Transplant Surgery from Menoufia University, Egypt, in 2012. Dr. Gad has published a number of research papers in reputed journals, coauthored a book chapter, and serves as a peer reviewer and editorial board member for several journals. He has

also participated in international conferences as a speaker as well as a member of organizing committees.

Contents

**Section 1**

We Know?

**Section 2**

**Section 3**

Fatty Liver Disease *by Ian James Martins*

*by Emad Hamdy Gad and Yasmin Kamel*

*by Subha Mary Varghese and Jibu Thomas*

Dysregulation of Bile Acids in Patients with NAFLD

*by Xinmu Zhang and Ruitang Deng*

Hepatocellular Carcinoma

*by Zaki A. Sherif*

**Preface III**

Introduction to Nonalcoholic Fatty Liver Disease **1**

**Chapter 1 3**

Experimental Work **11**

**Chapter 2 13**

Nonalcoholic Fatty Liver Disease and Its Associated Parameters **27**

**Chapter 3 29** Insulin Therapy and Autoimmune Disease with Relevance to Non Alchoholic

**Chapter 4 43**

**Chapter 5 77**

The Rise in the Prevalence of Nonalcoholic Fatty Liver Disease and

Introductory Chapter: Nonalcoholic Fatty Liver Disease - What Should

The Effect of *M. latifolia* Leaf Extract on High-Fructose Corn Syrup (HFCS)-Induced Non-alcoholic Fatty Liver Disease in Rat Models

### Contents



Preface

Non-alcoholic fatty liver disease (NAFLD) is a major medical challenge because of its increasing prevalence, difficulties in diagnosis, complex pathogenesis, and lack of approved therapies. It includes a group of conditions starting with simple liver steatosis, which can develop into nonalcoholic steatohepatitis (NASH) or fibrosis, which can progress to cryptogenic cirrhosis, portal hypertension, or hepatocellular

In the near future, it will become the major form of chronic liver disease in adults

It can be detected by noninvasive and invasive tools, and its treatment depends mainly on lifestyle modification to prevent disease progression and its related sequelae.

Divided into four sections, this book discusses some new topics related to NAFLD. The first section provides an introduction to NAFLD, the second section presents experimental work related to the disease, the third section discusses diseases related to NAFLD, and the final section examines new noninvasive tools to diagnose NAFLD.

The book provides information on NAFLD prevalence, etiology, pathogenesis,

**Emad Hamdy Gad**

Associate professor of hepatobiliary surgery, National liver institute, Menoufia University, Egypt

carcinoma (HCC), and finally end-stage liver failure.

pathology, diagnosis, and treatment as well.

and children and the leading indication for liver transplantation.
