**2. Methods**

*Search strategy.* For the purpose of this review, a systematic search of the literature databases (e.g., PubMed) by the EndNote software as well as other reference and electronic databases (e.g., Cochrane Library) have been searched by specifically chosen MESH terms, back to 1960. In total, while using the main four single terms ("cerebral", "sinus", "venous", "thrombosis") and combinations thereof, 4049 peer-reviewed titles have been initially found which have been later reduced down to 43 titles, among which 25 review papers have been also identified. Many references for this review came from the authors' own archives. Two of us (PAA, BDD) independently reviewed all 43 titles for inclusion as retrieved as above and 35 of them were decided to be included. Additionally, through hand-searching the references of the selected articles and other relevant electronic sources (e.g., Google Scholar), several additional relevant titles were also reviewed for inclusion. Finally, out of the initially 4049 identified titles and all other relevant titles, 39 articles were studied and included in this review. Any disagreements between the original reviewers have been resolved by a third, blinded reviewer (NTC); any further discrepancies have been solved by an open consensus among all of the reviewers.
