**Section 2**

**Venous Thromboembolism in Certain Groups of Patients** 

Pathophysiology and Clinical Aspects of 34 Venous Thromboembolism in Neonates, Renal Disease and Cancer Patients

Weisberg IS, Park E, Ballman KV, Berger P, Nunn M, Suh DS, et al. (2003). Investigations of

Wilcken DE & Wilcken B. (1967). The pathogenesis of coronary artery disease. A possible

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1079-1082, ISSN: 0021-9150.

a common genetic variant in betaine-homocystein methyltransferase (BHMT) in coronary artery disease. *Atherosclerosis*, Vol.167, (2003), pp. 205-214, ISSN: 0021-

role for methionine metabolism. *Journal of Clinical Investigation*, Vol.57, (1967), pp.

**3** 

*Perú* 

**Venous Thromboembolism in** 

*2Hospital Cayetano Heredia, City of Piura,* 

**Neonates, Children and Patients with** 

*3Hospital Nacional Almanzor Aguinaga Asenjo, City of Chiclayo,* 

Pedro Pablo García Lázaro1, Gladys Patricia Cannata Arriola2, Gloria Soledad Cotrina Romero3 and Pedro Arauco Nava3 *1Hospital Nacional Almanzor Aguinaga Asenjo, City of Chiclayo,* 

**Chronic Renal Disease – Special Considerations** 

Among children, the group of critically ill newborns presents the largest of population that suffering from thromboembolism. Making decisions regarding therapeutic strategies a challenge for the intensive care physician as the clinical significance of neonatal thrombosis varies from asymptomatic incidents to life or limb threatening events and, moreover,

This review focuses on the incidence, pathophysiology, risks factors, diagnosis and

The incidence of thromboembolic events in the pediatric age group is highest in neonates and infants <1 year of age (Monagle et al., 2008). Much of the published data regarding the epidemiology of neonatal venous thromboembolism (VTE) has come from national registry studies. The Canadian registry (Schmid & Andrew, 1995) reported 97 cases of wich 64 (66%) had venous involvement. The German neonatal registry (Nowak-Gottl et al., 1997) reported 79 cases of symptomatic thrombosis, including stroke. VTE accounted for 76% of cases. The

Male and female infants are affected with equal frecuency with the exception of renal vein

We must consider the multiple additive factors that contribute to the development of thromboembolism in neonates. Also, the hemostatic system of neonates is significantly

thrombosis, which has a male predominance for unclear reasons (Chalmers, 2006).

**1. Introduction** 

**1.2 Incidence** 

**1.3 Pathophysiologic** 

**1.1 Venous thromboembolism in neonates** 

appropriate evidence-based treatment algorithms are lacking.

overall incidence of symptomatic events was 0.51 per 10,000 births.

different from that of children and adults (Veldman, 2008).

treatment of venous thromboembolism in neonates
