Contents

#### **Preface XI**


Preface

deaths were hospital–acquired deaths.

populations, respectively.

and native-Americans, the incidence is lower.

diagnostic, prognostic and therapeutic.

management.

The estimated total number of symptomatic venous thromboembolism (VTE) events per annum within six European communities was 465,715 cases of DVT; 295,982 cases of PE and 370,012 VTE related deaths and almost three quarters of all VTE-related

Across the Atlantic, VTE is a major health problem in the USA with the annual incidence of VTE of 108 per 100,000 person/year among Caucasians, with 250,000 incident cases occurring annually among the Caucasians in the United States. Among African Americans, the incidence appears to be similar or higher, but among the Asian

In the Far East, VTE is not as common in Chinese as in Caucasians but is certainly not rare. The incidence of DVT and PE was reported to the 17.1 and 3.9 per 100,000

Understanding the etiology and pathogenesis of thrombosis is important for developing management strategy including preventive. In this book, we have selected two important etiological aspects of venous thrombosis to highlight microparticles and homocysteine. Flowcytometry has shown that the levels of platelet-derived microparticles and endothelial-derived microparticles to be elevated in deep vein thrombosis and cardiovascular disease can constitute to hypercoagulability due to circulating procoagulant microparticles. To that end, Dr. Enjeti from Australia assembled a very informative account, chapter 1, on the role of microparticles in hemostasis and venous thromboembolism and concluded that there are three potential areas where measuring the microparticles with respect to VTE may be relevant:

Hyperhomocysteinemia is a known risk factor for VTE. The risk of VTE recurrence in patients with hyperhomocysteinemia is unknown and so is the management of those patients after acute event of VTE. Dr. Plazar and Dr. Jurdana from Slovenia, Chapter 2, present a detailed updated account on this important topic including diagnosis and

VTE is an important clinical problem because of the associated morbidity and mortality and its negative impact on the Healthcare System. The medical literature is
