• **VTE in Acute Promyelocytic Leukemia**

The use of the differentiating agent all-trans-retinoic acid (ATRA) in the treatment of APL allowed achievement of complete remission in more than 90% of the cases and improved dramatically the coagulopathy typical of this disease (198). The modifications induced by ATRA in the balance between procoagulant and fibrinolytic properties of the pathological promyelocytes before complete differentiation have been proposed to induce a prothrombotic effect (199).
