**2.4 Cancer-related factors to incidence of VTE**


of diagnosis is a strong independent risk factor for developing VTE within the first year of cancer diagnosis (42-43).

d. **Rate of metastatic spread:** The incidence of VTE has been reported to correlate with the rate of growth and spread of the cancer cells. Fast growing cancer such as colonic and ovarian, has been associated with a higher rate of VTE (24-25, 41-42) and patients with advanced and metastatic disease had a higher risk of VTE (OR 19.8, CI 2.6–149). The observed incidence of VTE in ovarian, colorectal, pancreatic, lung and breast cancer supports the finding that advanced stage increases the risk of cancer associated VTE (24-25, 44).
