**2.5.1 Cell based haemostasis model**

The initial evidence for the role of MP in haemostasis comes from the cell based model. In this model plasma coagulation proteins are activated on the membrane surface after exposure to tissue factor. This leads to enzymatic cleavage of thrombin from prothrombin which ultimately converts fibrinogen to fibrin. This forms the fibrin clot and leads to haemostasis along with other components of the clot such as platelets and monocytes (Biro*, et al* 2003, Chirinos*, et al* 2005).
