**3.4.3.2 Management of Thrombosis in children with cancer**

The main challenge is to keep the balance of benefit and risk of an antithrombotic treatment, as most children are being treated with chemotherapy with intermittent thrombocytopenia and an unbalanced hemostatic system, both of which lead to potential bleeding complications. It is therefore strongly recommended not to use antithrombotic agents with potentially serious side effects such as thrombolytic agents, UFH or vitamin K antagonists.
