**3.4.2 New anticoagulants**

The limitations of the traditional anticoagulants are particularly obvious in pediatrics; hence, the promotion of the new drugs already approved in adults urgent. Yet there is but individual experience in children with the following substances: the pentasaccharides fondaparinux and idraparinux, and the direct thrombin inhibitors hirudin, bivalirudin, argatroban; ximelagatran has been withdrawn from the market because of hepatic toxicity.(Balsa, 2005; Kuhle et al, 2006).
