**Abstract**

The generation of antigen receptor diversity, and thus of the B-cell repertoire, is the result of very complex immunogenetic mechanisms. So, this chapter gives a brief overview on immunoglobulin (IG) gene organization and gene rearrangements, as well as the main mechanisms of immunoglobulin repertoire development.

**Keywords:** B-cell antigen receptor diversity, immunoglobulin gene organization, immunogenetic mechanisms
