Contents



Preface

This book is a collection of harmonious chapters contributed by different authors. It sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and

The Introductory chapter describes succinctly the main features of immunoglobulins, phases of B-cell ontogeny, and B-lymphoid lineage markers, as well as diseases

Chapter 2 focuses on the molecular description of the immunogenetic mechanisms responsible for the generation of B-cell antigen receptor diversity by giving a brief

Chapter 3 focuses on clinical and etiopathogenic features, prognosis, treatment,

Chapter 5 reviews the morphological, clinical, and etiopathogenic aspects, as well as

Chapter 7 specifically investigates the influence of splenectomy on the composition

I really hope that this book will be interesting and useful for clinicians, biologists, researchers, teachers, and graduate students of both doctoral and master's degrees

I would like to thank all the collaborators who participated in the conception of this book. I would also like to express my warmest thanks to Ms. Sandra Maljavac, Author Service Manager, for her great patience in developing this work and the coordination with the authors. I would like to thank her and the team of IntechOpen

Laboratory of Applied Molecular Biology and Immunology,

**Mourad Aribi**

Algeria

University of Tlemcen,

Chapter 6 describes the importance of immunophenotypic characterization of B-cell precursors using flow cytometry in the detection of minimal residual disease

overview of immunoglobulin gene organization and gene rearrangements.

Chapter 4 provides a general description of B-cell lymphomagenesis.

the therapeutic features, of diffuse large B-cell lymphoma.

etiopathogenic aspects when it is transformed into a malignant cell.

The current book is structured into seven chapters:

and WHO classification of B-cell lymphomas.

related to B-cell abnormalities.

in acute leukemia.

of B-cell subpopulations.

in the field of immunology.

for their trust and help in making this book.
