**1. Introduction**

Non-Hodgkin lymphomas (NHL) are the most common type of lymphoma, accounting for roughly 85% of this category of lymphoid neoplasia. NHL are most commonly classified as B-cell, T-cell, and natural killer (NK) cell lymphomas, according to their cell of origin. Diffuse large B-cell lymphoma (DLBCL) is a heterogenous class of aggressive lymphoma and is considered as the most common subtype of NHL. Several genetic anomalies such as point mutations, numerical alterations, and, more rarely, translocations and gene amplifications play a role in the pathogenesis of this class of B-cell lymphoma and have been related to specific histological and immunophenotypic subtypes [1].
