3.1.4.1 Tonic BCR signal and notch activation

A so-called BCR-mediated positive signaling tonic signal and activation of Notch pathway, more precisely of Notch2, which is induced following the interaction with delta-like canonical Notch ligand 1 (DLL-1) expressed on splenic endothelial niches and required for marginal zone (MZ) B-cell development [32], allow the triggering of a first differentiation by a lineage cell choice that does not involve the antigenic specificity.
