*5.2.1.3 Immune responses to protein antigens and B-cell cooperation with CD4+ Tfh cells*

Only CCs that express a high affinity receptor for epitopes of the antigen presented in its native form by the FDCs and that can capture it are selected efficiently. These selected CCs process the antigen and present antigen-derived peptides bound to MHC II molecules to antigen-specific CD4<sup>+</sup> Tfh cells, which have been shown to develop immediately from naive CD4+ T-cells during antigen priming by dendritic cells in T-cell zones [46] (comment in [47]). The Tfh cells then give survival and differentiation signals to B-cells, which can then undergo CSR and mature either in LLPCs or in memory B-cells.
