**6.2 Chronic lymphocytic leukemia/small lymphocytic lymphoma**

Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are used interchangeably by the degree of peripheral blood lymphocytosis. CLL is the most common leukemia of adults with absolute lymphocyte count >5000 per mm3 . The median age at diagnosis is 60 years. SLL constitutes only 4% of NHLs and has lymph node involvement The common genetic anomalies associated are deletions of 13q14.3, 11q, and 17p, and trisomy 12q [1, 25]. Patients are usually asymptomatic at diagnosis and can present with easy fatigability, weight loss, and anorexia. Generalized lymphadenopathy and hepatosplenomegaly are present in 50–60% of patients. The leukocyte count is high in most cases; leukopenia can be seen in individuals with SLL and marrow involvement.
