*6.4.3 Treatment and prognosis*

MCL is usually not curable with conventional chemotherapy, and most patients succumb to organ dysfunction caused by tumor infiltration. The prognosis is poor with median survival of only 3–4 years. The blastoid variant is associated with even shorter survivals. Hematopoietic stem cell transplantation and proteasome inhibitors are newer therapeutic approaches that show some promise [1, 25].
