Meet the editor

Matthew Summers received his BS degree in Biochemistry from the University of Delaware and his PhD in Cell and Molecular Biology from the University of Pennsylvania for his work on the E3 ubiquitin ligase and tumor suppressor CHFR. As a postdoctroral fellow at Stanford University and Genentech, Inc., his research focused on the mechanisms and regulation of the anaphase promoting complex/cyclosome ubiquitin ligase. He is currently

an associate professor at Ohio State University and a member of the OSU-Comprehensive Cancer Center. Research in the Summers lab focuses on the interplay between cellular checkpoints and the ubiquitin proteasome system to regulate cellular growth and genome stability.

Contents

**Section 1**

**Preface III**

Roles of the UPS in Cellular Regulation and Disease **1**

**Chapter 1 3**

**Chapter 2 25**

**Chapter 3 47**

**Chapter 4 69**

**Chapter 5 87**

**Chapter 6 105**

Enzymes and Mechanisms within the UPS **117**

**Chapter 7 119**

**Chapter 8 157**

Ubiquitin Signaling in Regulation of the Start of the Cell Cycle

E3 Ubiquitin Ligases in Cancer and Their Pharmacological Targeting

The Role of Lysine 63-Linked Ubiquitylation in Health and Disease

Ubiquitin Carboxyl-Terminal Hydrolase L1 in Parkinson's Disease

New Insights into the Mechanisms Underlying NEDD8 Structural

ADP-Ribosylation of the Ubiquitin C-Terminus by Dtx3L/Parp9

*by Paola Pontrelli, Francesca Conserva and Loreto Gesualdo*

Regulation of Selective Proteolysis in Cancer

Processes that Regulate the Ubiquitination of Chromatin

*by Michael James Emanuele and Taylor Paige Enrico*

and Chromatin-Associated Proteins *by Alexander E. Hare and Jeffrey D. Parvin*

*by Joseph Y. Ong and Jorge Z. Torres*

*by Pai-Sheng Chen*

**Section 2**

*by Dang Thi Phuong Thao*

and Functional Specificities

*by Teddy Kamata and Bryce Paschal*

*by Elena Santonico*

## Contents


#### **Chapter 9**

Structural Insight into Regulation of the Proteasome Ub-Receptor Rpn10 *by Tal Keren-Kaplan, Ilan Attali, Olga Levin-Kravets, Oded Kleifeld, Shay Ben-Aroya and Gali Prag* 

#### **Chapter 10**

Zinc-Binding B-Box Domains with RING Folds Serve Critical Roles in the Protein Ubiquitination Pathways in Plants and Animals *by Michael Anthony Massiah* 

**185** 
