**7. Comments**

The coronary angiography of patients with coronary ischemia determined atherosclerotic disease with possibility of the presence of coronary artery anomalies, but also coronary angiography may reveal coronary artery anomaly without the presence of atherosclerotic changes. The ectopic origin from opposite sinus of coronary artery anomalies that presents with atherosclerotic changes continues to exist as a challenge during treatment in interventional cardiology.

The atherosclerotic coronary artery disease leads to the need of coronarography which can find out the presence of coronary artery anomalies. We should think about these anomalies during coronarography knowing that based on type of these anomalies and considering the vulnerability to atherosclerosis will be determined the method of the treatment.

*Vascular Biology - Selection of Mechanisms and Clinical Applications*
