Meet the editor

Dr. Marcelo González studied Biochemistry at the Universidad de Concepción, Chile, and has a Doctoral degree in Physiological Sciences from the Universidad Católica de Chile. From 2009 he has been working at the Universidad de Concepción, first in the Department of Physiology and now in the Department of Obstetrics and Gynecology. His research interest include the description of placental vascular regulation mechanisms, both in

physiological conditions and in pregnancy diseases such as gestational diabetes and preeclampsia. In his laboratory, scientists use different methods of cellular biology, molecular biology, biochemistry, and vascular reactivity to elucidate the mechanisms of vascular regulation from the molecular interactions to organ function. Recently, his work has focused on the study of potassium channel regulation and its interaction with nitric oxide signaling in the human placenta, to determine the potential alterations of these mechanisms in gestational diabetes. He has published 32 articles in WOS journals and 4 book chapters.

Contents

**Section 1**

*and Sijia Liu*

*and Dai-Min Zhang*

Endothelial Dysfunction

**Section 2**

and Treatment

Nitric Oxide and Oxidative Stress-Mediated Cardiovascular Functionality: From Molecular

Potassium Channels in the Vascular Diseases

*by Weilue He, Maria Paula Kwesiga, Eyerusalem Gebreyesus* 

*by Yan-Rong Zhu, Xiao-Xin Jiang, Peng Ye, Shao-liang Chen* 

The Role of Physical Activity on Insulin Resistance-Associated

L-Arginine/Nitric Oxide Pathway and KCa Channels

*by Shruti M. Gandhi, Eric S. Nylen and Sabyasachi Sen*

Therapeutic Applications and Mechanisms of YC-1:

*by Chieh-Hsi Wu, Chun-Hsu Pan and Ming-Jyh Sheu*

Giant Cell Arteritis: Current Advances in Pathogenesis

*by Marília A. Dagostin and Rosa M.R. Pereira*

A Soluble Guanylate Cyclase Stimulator

Mechanism to Cardiovascular Disease

in Endothelial Cells: A Mini-Review *by Marcelo González and José Carlos Rivas*

**Preface XI**

Physiological and Pathophysiological Mechanisms **1**

**Chapter 1 3**

**Chapter 2 27**

**Chapter 3 47**

**Chapter 4 63**

**Chapter 5 73**

Vascular Diseases and Clinical Applications **91**

**Chapter 6 93**
