*2.5.2 Inflammatory bowel disorder (IBD)*

IBD is a long term degenerative disease which involves the severe irritation of G.I.T tract that leads of watery and bloody diarrhea along with the abdominal pain IBD affects the small intestines and a portion of large intestines that is colon and it includes three different conditions which are Crohn's disease, ulcerative colitis (UC) and pouchitis. The other factors that are associated with the onset of disease include the genetic factors, ecological factors, oxidative stress and the weakened immune system [25].

Crohn's disease and ulcerative colitis are long term diseases of the gastro-intestinal tracts that are associated with the inflammation of the immune and likely are because there is absence of balance of the natural immunity with the surroundings and the with the advancement of the culture [26]. Intake of probiotic bacteria can possibly balance out the immunological boundary in the gut mucosa by diminishing the production of nearby proinflammatory cytokines [27–29]. *Bifidobacterium infantis* 35,624 helps in elevating the symptoms of abdominal pain, bloating, passage of gas, straining, bowel dysfunction and incomplete evacuation in the patients of IBD. It has been observed through recent studies that Probiotic supplementation is very helpful in elevating the symptoms of IBD and in some cases even the medical therapy can be replaced by probiotic supplementation. However it is not recommended for the Crohn's disease as the data does not support the use of probiotics. Therefore Probiotics have shown promising role in reducing the symptoms of ulcerative colitis but not in the case of Crohn's disease [30].
