*4.4.5 Prebiotics assist in the management of cognition*

Worldwide, Schizophrenia is the 25 leading cause of disabilities that decrease the life about 10–20 years. Inappropriate treatment like pharmacotherapy in the administration of cognitive defects and weight gain are recognized a significant contributors of these diseases; therefore there is a need to develop such treatments that alleviate one, or both, of these diseases would be very helpful. By using gut microbiome from dietary source like prebiotics for the treatment of these diseases may be one such intervention. Moreover, prebiotics also effect breakdown, and in case of obesity they rise the concentration of anorexigenic gut hormones such as peptide tyrosine tyrosine, glucagon-like peptide 1 and leptin and decrease the amount of orexigenic hormones such as ghrelin [123].
