**Author details**

Heng-Wei Cheng1 \*, Sha Jiang2 and Jiaying Hu3

1 USDA-Agricultural Research Service, Livestock Behavior Research Unit, West Lafayette, IN, USA

2 College of Animal Science and Technology, Southwest University, Chongqing, PR China

3 Department of Animal Sciences, Purdue University, West Lafayette, IN, USA

\*Address all correspondence to: heng-wei.cheng@ars.usda.gov

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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*Gut-Brain Axis: Probiotic,* Bacillus subtilis*, Prevents Aggression via the Modification…*

[10] Yang H, Duan Z. The local

defender and functional mediator: Gut microbiome. Digestion. 2018;**97**:137-145

[11] Bjerre K, Cantor MD, Nørgaard JV, Poulsen HD, Blaabjerg K, Canibe N, et al. Development of *Bacillus subtilis* mutants to produce tryptophan in pigs. Biotechnology Letters. 2017;**39**:289-295

[12] Hussain S, Andrews D, Hill BC. Using tryptophan mutants to probe the structural and functional status of BsSCO, a copper binding, cytochrome c oxidase assembly protein from *Bacillus subtilis*. Biochemistry. 2017;**56**:6355-6367

[13] Okada M, Sugita T, Abe I. Posttranslational isoprenylation of tryptophan in bacteria. Beilstein Journal of Organic Chemistry. 2017;**13**:338-346

2015;**28**:1202-1208

[14] Sheng QK, Yang ZJ, Zhao HB, Wang XL, Guo JF. Effects of l-tryptophan, fructan, and casein on reducing

ammonia, hydrogen sulfide, and skatole in fermented swine manure. Asian-Australasian Journal of Animal Sciences.

[15] Chen S, Wang M, Yin L, Ren W, Bin P, Xia Y, et al. Effects of dietary tryptophan supplementation in the acetic acid-induced colitis mouse model. Food & Function. 2018;**9**:4143-4152

[16] Gao J, Xu K, Liu H, Liu G, Bai M, Peng C, et al. Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism. Frontiers in Cellular and Infection

Microbiology. 2018;**8**:13

[17] Mukhtar K, Nawaz H, Abid S. Functional gastrointestinal disorders and gut-brain axis: What does the future hold? World Journal of Gastroenterology. 2019;**25**:552-566

[18] Wen H, Feng L, Jiang W, Liu Y, Jiang J, Li S, et al. Dietary tryptophan

*DOI: http://dx.doi.org/10.5772/intechopen.86775*

[1] De Almeida RM, Cabral JC, Narvaes R. Behavioural, hormonal and neurobiological mechanisms of aggressive behaviour in human and nonhuman primates. Physiology &

**References**

Behavior. 2015;**143**:121-135

[2] Arneth BM. Gut-brain axis biochemical signalling from the gastrointestinal tract to the central nervous system: Gut dysbiosis and altered brain function. Postgraduate Medical Journal. 2018;**94**:446-452

[3] Cussotto S, Sandhu KV, Dinan TG, Cryan JF. The neuroendocrinology of the microbiota-gut-brain axis: A behavioural perspective. Frontiers in Neuroendocrinology. 2018;**51**:80-101

[4] Di Sabatino A, Lenti MV, Cammalleri L, Corazza GR, Pilotto A. Frailty and the gut. Digestive and Liver Disease.

[5] Farzi A, Fröhlich EE, Holzer P. Gut microbiota and the neuroendocrine system. Neurotherapeutics. 2018;**15**:5-22

[6] Gerhardt S, Mohajeri MH. Changes of colonic bacterial composition in parkinson's disease and other neurodegenerative diseases. Nutrients.

[7] Liu L, Zhu G. Gut-brain axis and mood disorder. Frontiers in Psychiatry.

[8] Lyte JM. Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics. BioEssays. 2011;**33**:574-581

[9] Lyte JM. Eating for 3.8 × 1013: Examining the impact of diet and nutrition on the microbiotagut-brain axis through the lens of microbial endocrinology. Frontiers in

Endocrinology. 2019;**9**:796

2018;**50**(6):533-541

2018;**10**. pii: E708

2018;**9**:223

*Gut-Brain Axis: Probiotic,* Bacillus subtilis*, Prevents Aggression via the Modification… DOI: http://dx.doi.org/10.5772/intechopen.86775*
