**1. Introduction**

As we know tooth decay and oral health is one of the most common worries in the world [1], and with widespread public concern about the use of industrial drugs to reduce dental caries, natural base treatments are highly welcomed, but the question is: Can probiotics be used as a therapeutic agent? A few years before 1908, the theory is drawn up according to this theory; the Bulgarian people have a longer life; the reason of longer life was Bulgarian people used more fermented products. These products have increased the health of their digestive system [2]. This theory won the Nobel Prize in Physiology and Medicine (1908) [3]. Since then, many publications that have referred to this theory said using probiotic products can be factor in improving the health of the digestive system, reproductive organs, and oral hygiene [4, 5]. Oral holes are environments with homeostasis conditions, which affect the nutritional conditions and individual health conditions and conditions of the environment [3, 4, 6]. Probiotics, as nonpathogenic microorganisms, can have beneficial health benefits at low levels in food. They have the ability to change this homeostasis environment [3, 7]. Probiotic bacteria consist of two main groups of *Lactobacillus* and *Bifidobacterium*. The *Lactobacillus*, as a member of oral microbial flora, can play an important role in the microcosm balance of the oral cavity. Less information is available about the useful role of *Bifidobacterium* in oral cavity health [8, 9].
