**Abstract**

Most research work on plant source for medicines end up without the researcher reaching a conclusive indication of the implicated chemical name/structure for the cure claimed. A large majority stop at just authenticating the claimed folkloric use of the crude extract of the said plant. A thorough authentication experimental process from plant identification, literature, and methodology to bioassay-guided pursuance of the active compound is carefully penned down. In addition, a vivid descriptive literature of the separation process, difficulty encountered, financial implication of the process, and joy in achievement of results is discussed in a friendly read. Furthermore, a close of the chapter with a plea to researches to endeavor to provide answers in their quest, rather than unending questions.

**Keywords:** *Corchorus olitorius*, crude extract, separation, liquid-liquid partitioning, fractionation, column chromatography
