**Abstract**

Cancer has been a public health problem that has gained a lot of death. However, in spite of the advances in the diagnosis and treatment of cervical cancer, women follow the struggle versus this disease. Also, those patients suffer from limited efficacy and specificity, undesirable effects, drug resistance, and a high cost of treatments. Currently, several studies have demonstrated the efficiency of natural products, called bioactive compounds, against cervical cancer cell lines. Bioactive compounds, including polyphenols and phenolic acids or flavonoids, etc., have antioxidant and pro-oxidant properties. These compounds are efficacy and show high specificity because probably they act as anti-oxidant and pro-oxidant. The prooxidant activity obstructs growth factors related to different signalling pathways that trigger cancer. Although, usually this kind of compounds helps for dispatching the apoptosis in cervical cancer cell. The aim of this chapter is reviewing how bioactive compounds affect the signalling pathways.

**Keywords:** HeLa, cervical cancer, bioactive compounds, signalling pathway, polyphenols
