*Leptospirosis: Rising Nuisance for Cattle and Threat to Public Health DOI: http://dx.doi.org/10.5772/intechopen.82211*

disease. Among the Asian countries, the highest prevalence of leptospirosis was found in India. Leptospirosis is mainly transmitted by direct contact with infected urine, and bacteria are mainly entered through ruptured skin. In house IgM ELISA is highly specific technique for *Leptospira* diagnosis. However, among the serological test, ELISA is more sensitive test for *Leptospira* diagnosis. Most effective treatment for *Leptospira* is doxycycline or azithromycin; however, former is not recommended in pregnancy. However, in severe cases, blood transfusion is also a best choice to save the life of animal. At last, the most effective way to control the disease is vaccination at early age of life following booster doses to avoid from more severe economic losses.
