**7.2 Vaccination**

The optimal control regime for leptospirosis is to prevent clinical disease and exfoliation in the urine in animals exposed to different serotypes of *Leptospira*. The most common method of controlling leptospirosis in cattle is vaccination and selective treatment. In addition, proper quarantine procedures should be implemented to prevent the introduction of hajo in the herd by buying infected animals. However, leptospirosis and wild animals gave rise as a carrier of the prevalence of serotypes of hardjo infections in cattle, mainly to prevent the overall impact of leptospirosis in most dairy products and Rieben beef failure. This is impossible. Thus, vaccination depends on an increase in the resistance of an animal to leptospiral serotype infection in this area. In all cases, the effort (buildings, under the control of rodents around swamps and creeks, for example, surround) must be made in order to limit direct and indirect contact between the cattle and Leptospirosetragern. In addition, proper quarantine procedures should be implemented to prevent the introduction of hajo in the herd by buying infected animals. However, leptospirosis and wild animals gave rise as a carrier of the prevalence of serotypes of hardjo infections in cattle, mainly to prevent the overall impact of leptospirosis in most dairy products and Rieben beef failure. This is impossible. Thus, vaccination depends on an increase in the resistance of an animal to leptospiral serotype infection in this area. The leptoral vaccine currently available for cattle in the United States is a 5-fold bacterial whole cell vaccine, including Pomona, Canicola, Icterohaemorrhagiae, Grippotyphosa, and Hardjo serotypes. These antigens can also be used in various combinations of other viral and bacterial vaccines. In the United States, a series of experimental studies and field data are available from the United States. Typical leptospirosis vaccines are Hajo kidney serotype infection, urinary tract infection or fetus (ha-ha type). This does not exclude the fact that the state indicates that the country is isolated from the United States. Many of the available Hardjo vaccines were approved many years ago in rigorous efficacy studies that mimic the natural route of exposure, and the last method to determine whether the Hardjo serotypes are infected with cattle is Hardjo stocks which did not use the serotype. However, recently two Hardjo vaccine serotypes have been widely studied using appropriate strains and methods. Compared to many other Hardjo serotype vaccines, these two products have shown excellent protection against infection and Hardjo hemoglobin isolation [75].
