We are IntechOpen, the world's leading publisher of Open Access books Built by scientists, for scientists

4,100+

Open access books available

116,000+

International authors and editors

120M+

Downloads

Our authors are among the

Top 1%

most cited scientists

12.2%

Contributors from top 500 universities

Selection of our books indexed in the Book Citation Index in Web of Science™ Core Collection (BKCI)

### Interested in publishing with us? Contact book.department@intechopen.com

Numbers displayed above are based on latest data collected. For more information visit www.intechopen.com

## Meet the editor

Dr. Ghulam Md. Ashraf is currently working as an associate professor at King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia. His current research interest covers proteomics, neurobiology, cancer, and nanobiology. He has to his credit 164 publications ranging from peer-reviewed journal articles, books, and book chapters published with scholarly publishers (total citations: 1600, h-index: 20, i10-index: 42). Dr. Ashraf

is involved in an editorial capacity in many internationally reputed journals, and has been involved in seven research projects funded by various agencies in Saudi Arabia. He is a member of several renowned professional associations and organizations. Dr. Ashraf received his PhD in Biochemistry from Aligarh Muslim University, India, in 2010.

**Preface III**

**Chapter 1 1**

**Chapter 2 9** Recent Advance of Enzyme Targets for the Management of Vascular Dementia

**Chapter 3 21** Metabolic Syndrome and Its Biomarkers in the Development and Progression of

**Chapter 4 37**

Recovery Intervention to Promote Social Connectedness through Social Recreational Programs for Persons with Dementia: A Critical Analysis *by Winnie Sun, Shelby-Lynne Clarke, Hanaan Madahey and Ping Zou*

Introductory Chapter: Alzheimer's Disease—The Most Common

*by Arunachalam Muthuraman, Narahari Rishitha and Johurul Islam*

*by Md. Sahab Uddin and Ghulam Md. Ashraf*

Alzheimer's Disease and Other Dementias *by Teresa Juárez-Cedillo and Susan Drier-Jonas*

Cause of Dementia

Contents

## Contents


Preface

*Advances in Dementia Research* provides a comprehensive overview of Alzheimer's disease. It has been found that the presence of the components of metabolic syndrome in an earlier life, especially middle age, increases the risk of Alzheimer's disease, although it has recently been suggested that these components may begin the progression to dementia as early as adolescence. This book represents the association between the components of metabolic syndrome and Alzheimer's disease. Vascular dementia is the second most common cause of dementia after Alzheimer's disease. The basic understanding of vascular dementia and its molecular mechanisms is a complex phenomenon. Vascular dementia associated with neurodegeneration and cognitive impairments is caused by multiple complications of the neurovascular system. This book attempts to explore the recent advancements of enzyme targets for the management of vascular dementia. Furthermore, this book highlights the effectiveness of social recreational programs as an example of a recovery intervention for persons with dementia that focuses on reducing the risk of social isolation associated with dementia. Together the insightful research presented in this book provides valuable information for those involved in this area, including neuroscientists, researchers, medical professionals,

academicians, and upper-level students, as well as industry professionals.

**Ghulam Md. Ashraf**

King Abdulaziz University, Jeddah, Saudi Arabia

King Fahd Medical Research Center,
