**2.2 ALS-008176**

ALS-008176, a prodrug of a cytidine nucleoside analogue, decreased viral load and more readily cleared RSV than placebo in a randomized, double-blind clinical trial in healthy adults [25]. However, participants' preexisting immune memory, which may promote RSV clearance, was not assessed [26]. A randomized, double-blind Phase I study assessing both a single and multiple ascending dosing in hospitalized infants (Clinicaltrials.gov identifier #NCT02202356) was completed in February 2018, but results have not been published yet.
