**5. Operating procedures for antischistosomal drug screening and the techniques employed**

In recent years, the search for new anthelmintics has intensified, but little significant progress has been made in developing new techniques. The *in vitro* drug screening approaches must take into account some specic concerns, particularly to be simple and inexpensive. Important methodologies can objectively and rapidly distinguish helminth viability or phenotype. *In vitro* screening could identify novel anthelmintics and could eventually translate into practical applications. Herein, a general overview is given of the most common methodologies used for screening antischistosomal compounds and their effects on the whole organism.
