**Meet the editors**

Prof. Dr Ahmed RG received his Ph.D. in Developmental Biology (Developmental-Toxicology/-Endocrinology) from Beni-Suef University, Egypt and received research training (postdoctoral fellowship) as a visiting scholar at the Katholic University, Belgium. Also, he has outstanding records of scientific and academic accomplishments with multiple research funding projects, numerous pub-

lications (books/papers) in highly prestigious journals, and various presentations in both national and international conferences. He is a member of several eminent societies, organizations, and schools. He has also served as a scientific editor and reviewer for national and international research institutions. He has been awarded several international prizes as follows:

2019-2020: Bentham Ambassador in Bentham Science Publishers. 2019: International Academic Mentor-Publons (Web of Science). 2018: Publons Peer Review Award (one of the top 1% of peer reviewers in assorted) [Honoring the Sentinels of Science and Research]. 2018: Certified PUBLONS Academy Peer Reviewer. 2017: Publons Peer Review Award (one of the top 1% of peer reviewers in Science and Research) [Honoring the Sentinels of Science and Research].

2010: Honor from Society for Endocrinology, UK.

Prior to working at a major university of health sciences, Associate Prof. Ahmet Uçar received his degrees in pediatrics and then in pediatric endocrinology, achieving high honors at the national exams. He has been actively working in the field of pediatric endocrinology and diabetes, and he has contributed significantly to the definition of the characteristics of pubertal variants in chil-

dren. He successfully completed a thesis on Turner syndrome, which has dramatically increased his interest in and dedication to Turner syndrome ever since. He is an active member of the Turner Syndrome Study Group in Turkey. He is also a member of the Endocrine Society and the European Society of Paediatric Endocrinology.

Contents

**Preface VII**

Ahmed R.G.

**Section 2 Growth Disorders 9**

Jesús Devesa

Jesús Devesa

Chapter 4 **Fetal Growth Restriction 69**

**Pregnancy 91**

Barrera-Barrera

Mayank Choubey

Chapter 1 **Introductory Chapter: Growth Disorders 3**

**Impairment? Part I 11**

**Impairment? Part II 43**

Chapter 2 **Growth Hormone Deficiency: Is It Just a Problem of Growth**

Chapter 3 **Growth Hormone Deficiency: Is It Just a Problem of Growth**

Cahuana Bartra and Maria Dolores Gómez Roig

Chapter 5 **The Role of the Human Growth Hormone Gene Family in**

Chapter 6 **Growth Hormone and Insulin-like Growth Factor-I: Novel Insights into the Male Reproductive Health 113**

Edurne Mazarico Gallego, Ariadna Torrecillas Pujol, Alex Joan

Hugo A. Barrera-Saldaña, Belinda M. Contreras-Garza and Silvia A.

**Section 1 Introduction 1**

## Contents

**Preface XI**



#### **Section 3 Acromegaly 129**


Preface

acromegaly.

This book, *Growth Disorders and Acromegaly*, aims to provide an overview of the recent prog‐ ress in growth disorders including growth hormone deficiency (GHD) and acromegaly, and worldwide research in growth failure, with a focus on different research areas relevant to these problems. These include the effects of growth hormone (GH) and its deficiency on the brain, cardiovascular system, female gonadal system (ovarian functioning), liver, kidney, adrenal gland, skeletal muscles, bones, hematopoietic system, and gastrointestinal system in children and adults. Also, this book reviews the causes and diagnoses of fetal growth defect including intrauterine growth restriction (IUGR) and fetal small for-gestational-age (SGA). It describes the role of the pituitary/placental human GH (hGH) and insulin-growth factor-1 (IGF-1) gene families during pregnancy. The authors have also contributed articles not only on the GH replacement therapy during pregnancy but also on the role of hGH locus in pio‐ neering personalized medicine. This book proposes the impact of GH on germ cell prolifera‐ tion/migration, testicular development, pubertal maturation, testicular steroidogenesis, and erectile function. It follows the impact of GH/Insulin/IGF-1 signaling in the regulation of tes‐ ticular metabolic and energy status. Finally, this book illustrates the therapeutic potentials of GH on reproductive health and male infertility, the pegvisomant, colorectal neoplasms in acromegaly, epidemiology and underlying mechanisms and the surgical managements of

**Ahmed, R.G.**

**Ahmet Uçar**

MD, Associate Professor

Prof. Dr. of Developmental and Experimental Biology Division of Anatomy and Embryology, Zoology department

Pediatric Endocrinology and Diabetes Clinic, Istanbul, Turkey

University of Health Sciences, Şisli Hamidiye Etfal Education and Research Hospital

Faculty of Science, Beni-Suef University, Egypt

#### Chapter 9 **The Surgical Management of Acromegaly 155** John L. Kilgallon and Edward R. Laws

## Preface

**Section 3 Acromegaly 129**

**VI** Contents

Chapter 7 **Pegvisomant in Acromegaly and Gigantism 131**

**Underlying Mechanisms 145**

Claire Briet, Valentine Suteau and Patrice Rodien

Chapter 8 **Colorectal Neoplasm in Acromegaly: Epidemiology and**

Masaaki Yamamoto and Yutaka Takahashi

Chapter 9 **The Surgical Management of Acromegaly 155** John L. Kilgallon and Edward R. Laws

This book, *Growth Disorders and Acromegaly*, aims to provide an overview of the recent prog‐ ress in growth disorders including growth hormone deficiency (GHD) and acromegaly, and worldwide research in growth failure, with a focus on different research areas relevant to these problems. These include the effects of growth hormone (GH) and its deficiency on the brain, cardiovascular system, female gonadal system (ovarian functioning), liver, kidney, adrenal gland, skeletal muscles, bones, hematopoietic system, and gastrointestinal system in children and adults. Also, this book reviews the causes and diagnoses of fetal growth defect including intrauterine growth restriction (IUGR) and fetal small for-gestational-age (SGA). It describes the role of the pituitary/placental human GH (hGH) and insulin-growth factor-1 (IGF-1) gene families during pregnancy. The authors have also contributed articles not only on the GH replacement therapy during pregnancy but also on the role of hGH locus in pio‐ neering personalized medicine. This book proposes the impact of GH on germ cell prolifera‐ tion/migration, testicular development, pubertal maturation, testicular steroidogenesis, and erectile function. It follows the impact of GH/Insulin/IGF-1 signaling in the regulation of tes‐ ticular metabolic and energy status. Finally, this book illustrates the therapeutic potentials of GH on reproductive health and male infertility, the pegvisomant, colorectal neoplasms in acromegaly, epidemiology and underlying mechanisms and the surgical managements of acromegaly.

#### **Ahmed, R.G.**

Prof. Dr. of Developmental and Experimental Biology Division of Anatomy and Embryology, Zoology department Faculty of Science, Beni-Suef University, Egypt

#### **Ahmet Uçar**

MD, Associate Professor University of Health Sciences, Şisli Hamidiye Etfal Education and Research Hospital Pediatric Endocrinology and Diabetes Clinic, Istanbul, Turkey

**Section 1**

**Introduction**

**Section 1**
