**Acknowledgements**

This work was supported by the US National Institutes of Health (NIH) Grants HL125228 and HL106843 and HL142973 (to M.C.G. and Z.G.), the US Department of Veteran Affairs I01BX002141 (to Z.G.), and the Institutional Development Award (IDeA) from the US National Institute of General Medical Sciences of NIH, under grant number P30 GM127211.
