Preface

Squamous cell carcinoma (SCC) is one of the most globally encountered kinds of malignancies. It is an aggressive metastasizing disease that can affect any human organ and maintains a high mortality rate despite all the research development. Currently, multiple new therapeutic methodologies founded on genetic identification have succeeded in confirming efficacy in extending disease-free survival, and were basically adopted in various scientific foundations. Targeted and immunotherapies are two different strategies of treatment that have remarkably succeeded in adding a fingerprint to the conventional chemo- and radiotherapies in prolonging the overall survival of several cancer types, keeping in mind the considerable side effects that may arise from their administration.

This book, therefore, was planned to cover every single data that might correlate with SCC, comprising kinds, classifications, investigative approaches, staging and treatment. It also aims to emphasize the latest approved therapeutical approaches with the ongoing promising clinical trials that may add benefit to the existing therapies. It also opens the opportunity for researchers and treating physicians to display and thoroughly present their newly discovered data and updated scientific results in their various SCC research, thus, paving the road for further investigations in the realm of cancer therapy.

Finally, I would like to express my sincere acknowledgments to the book authors and IntechOpen team that have contributed to the successful publication of this book.

**II**

**Section 6**

Cell Carcinomas

*and Ramon Garcia-Escudero*

Molecular Aberrations in Squamous Cell Carcinoma **99**

**Chapter 6 101**

Comprehensive Molecular Characterization of Squamous

*by Corina Lorz, Carmen Segrelles, Ricardo Errazquin* 

**Hamid Elia Daaboul, MD, PhD**

Surrey University, London, UK

Medical Oncologist, Researcher in the Mode of Action of New Anticancer Drugs, Lebanese American University, Lebanon

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