Preface

*Breast Cancer Biology* systematically describes breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some added focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book starts with an introduction on genetics, survival, and pathophysiology of breast cancer in Section 1. In Section 2, the molecular and cellular biology of breast cancer is presented with definite signaling pathways, especially the existence of breast cancer hypoxia. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. Section 4 is focused on diet, exercise and other lifestyle factors for breast cancer prevention. This book provides a brief yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.

This book is a splendid compilation of six subjects associated with cancer covering a whole range of areas including breast cancer, signaling, genetics, mutation, cancer surviving, PI3K, AKT, Micro-RNA, chemo-resistance, hypoxia, and angiogenesis. Historically, prognosis and treatment choice making for breast cancer patients have been dictated by the anatomic amount of tumor spread. However, recently, breast cancer has become an assemblage of distinctive phenotypes with diverse prognoses, outlines of failure, and treatment responses. This book shows how biologically based assays and targeted therapies planned to exploit these unique phenotypes have intensely altered systemic therapy practice patterns and treatment consequences. This book aims to summarize the present data and provide practical framework for the integration of breast tumor biology into clinical practice.

Studies regarding ethnic, cultural, and personal differences in health beliefs and health care seeking behavior will yield important information for those providing care and setting policies. Also necessary is accurate, reliable, unbiased information on direct and indirect costs associated with genetic testing, prevention strategies, screening and diagnostic techniques, or a given treatment; such information is a critical component of realistic health care planning and delivery. An area of urgent importance is the effect of managed care on breast cancer screening, detection, treatment, and follow-up. There is concern about the trade-off between quality and cost of health care.

This book is covering a comprehensive range of topics. It has been a delightful opportunity to edit this special edition along with team of co-editors. We greatly appreciate the work of all the contributors to this book and they have brought with them a remarkable diversity of perspectives and fields that is truly reflective of the complexity of the topic, and they have come together in this project to create a node of multidisciplinary collaboration in this field.

We acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information leading to significant progress in knowledge in the field in the recent years.

**II**

**Section 4**

Breast Cancer and Exercise *by Deniz Kocamaz and Tülin Düger*

Diet, Exercise and Other Lifestyle Factors for Breast Cancer Prevention **99**

**Chapter 6 101**

We acknowledge the support of the Human Genetics Centre and associated Hospital, Sher-I-Kashmir Institute of Medical Sciences, Director, SKIMS, India.

#### **Dr. Dil Afroze, Dr. Shazia Ali, Dr. Faheem Shehjar, Dr. Mohd Ishaq Dar and Dr. Natasha Thakur** Sher-I-Kashmir Institute of Medical Sciences, India

#### **Dr. Bilal Rah**

**1**

Section 1

Introduction on Breast

Cancer Governed by

Factors, Cell Cycle,

Initiation and Progression

Department of Medical Biotechnology, College of Applied Medical Science, Qassim University, Kingdom of Saudi Arabia

#### **Dr. Shailender S. Chauhan**

University of Arizona, USA

### Section 1
