Meet the editors

Hande Turker is a neurologist and clinical neurophysiologist. She has dealt with headache, neuropathic pain, neuromuscular diseases, dystonia, and electromyography and evoked potentials for nearly 30 years. She is the author of many publications, including several book chapters on evoked potentials and electromyography. Her main interests other than clinical neurophysiology are neuromuscular diseases with a special stress on neuropathies

and neuropathic pain, headache, and botulinum toxin injections in movement disorders. She has been working at Ondokuz Mayıs University, Samsun, Turkey, since 2003. She is a professor of neurology and a lecturer, and teaches headache, neuropathic pain, neuromuscular diseases, and electromyography and evoked potentials at the same university, where she founded the "Evoked Potential Lab" and directed the EMG and EP Unit between 2003 and 2010. She is also the author of IntechOpen book chapters, including "Middle and long latency auditory evoked potentials and their usage in fibromyalgia and schizophrenia," "Neurological complications of hypothyroidism," and "Surface electromyography in sports and exercise." She is the editor of a number of IntechOpen books, including *Electrodiagnosis in New Frontiers of Clinical Research* and *Current Perspectives on Lesser-Known Aspects of Headache*. She has published more than 80 manuscripts, mostly original studies, speaks several foreign languages other than English, and is happily married.

Leonel Garcia Benavides, MD and PhD, is a plastic and reconstructive surgeon, certificate number 940. He holds a PhD in Pharmacology from the University of Guadalajara, and is a member of the National Staff of Investigators, level 1. Dr. Benavides has been a research professor at the University of Guadalajara since 1987, is a member of the Clinical and Experimental Institute of the University of Guadalajara, and a member of the Staff

of Specialists in the Plastic Surgery Department of the Civil Hospital of Guadalajara. He has experience in design, conduction, and analysis of clinical trials, is a coordinator of clinical investigation in the PhD program at the Health Sciences University Center of the University of Guadalajara, and has expertise in fibrogenesis and regeneration. Dr. Benavides is a member of AMCPER (Plastic and Reconstructive Surgery Mexican Association).

Dr. Guillermo Ramos Gallardo is a board-certified plastic surgeon specializing in facial, breast, and body reconstructive surgeries. He was trained at different hospitals in Mexico and the United States, with recognition from the Universidad Nacional Autonoma de Mexico, Universidad de Guadalajara, and University of Alabama at Birmingham. He is part of the staff at the Nuevo Hospital Civil de Guadalajara and he consults at the beautiful

beach of Puerto Vallarta near the Pacific Ocean.

Miriam Méndez del Villar, PhD, is a professor and investigator at the University Center of Tonalá at the University of Guadalajara (Guadalajara, Jalisco, Mexico). She is Chief of the Department of Biomedical Sciences at the same university center. She is a nutritionist and obtained her PhD in Pharmacology in 2017; a year later she started her career as a teacher and researcher. She has published a total of 17 papers in the clinical research field,

Contents

**Section 1**

*by Tayir Alon and Vera Bril*

*and Leonel Garcia Valdés*

*and Abhishek Biswas*

Nerve Regeneration

**Section 2**

**Preface XI**

Mononeuropathies, Diagnosis and Treatment **1**

**Chapter 1 3**

**Chapter 2 15**

**Chapter 3 19**

**Chapter 4 31**

**Chapter 5 49**

Peripheral Nerve Injury, Diagnosis and Treatment **65**

**Chapter 6 67**

Focal Upper Limb Mononeuropathies in Patients with Diabetes Mellitus

Introductory Chapter: Current State of Carpal Tunnel Syndrome

*by Leonel García Benavides, Miriam Méndez del Villar*

*by Mohamed A. Bedewi, Daniele Coraci and Sherine Swify*

Orthotic Treatment Overview of Carpal Tunnel Syndrome

*by Hasan Md Arif Raihan, Poly Ghosh, Prasanna Lenka, Ameed Equbal* 

Biological and Preclinical Evaluations of Designed Optically Guided Medical Devices with Light Scattering Modules for Carpal Tunnel

Biomaterials and Cellular Systems at the Forefront of Peripheral

*Sílvia Santos Pedrosa, Ana Lúcia Luís, Stefano Geuna, Artur Severo Proença Varejão and Ana Colette Maurício*

*by Rui Damásio Alvites, Mariana Vieira Branquinho, Ana Rita Caseiro,* 

Peripheral Nerve Imaging: Focus on Sonography

Syndrome Treatment and Surgical Procedure *by Ching-Cheng Huang and Ming-Che Chiang*

mainly related to cardiometabolic diseases. She participated as an investigator in 20 clinical trials, which has allowed her to be a member of the Mexican System of Investigators. Also, she has contributed to thesis direction of bachelor and PhD degree students, and has participated in the editing and writing of a number of books and book chapters.

## Contents



Preface

Neuropathies are intriguing subjects for clinicians, electromyographers, and peripheral nerve surgeons. The main reason for this assumption lies in the nature of these diseases, which still possess a number of secrets waiting to be discovered. This book contains current knowledge on neuropathies, which we believe you will find interesting. The subject of "neuropathies" comprises a number of topics, and each

This book was initially envisioned to solving problems in the diagnosis and therapy of neuropathies. The authors discuss the diagnosis and treatment of mononeuropathies, peripheral nerve injuries, and the new insights into the mechanisms of neuropathic pain. In some chapters of this book we also look at interesting and evocatory facts about interventional treatment options for neuropathic pain, which

This book should be read without prejudgment because the content may not be compatible with general but repeated assumptions and guidelines. However, I believe that this book may be an inspiration for many young investigators as well.

All in all, we have one major aim and that is to make you think deeply about neuropathies and neuropathic pain. We will be contented if we succeed.

**Hande Turker**

Turkey

Mexico

Ondokuz Mayis University,

**and Miriam Méndez Del Villar** University of Guadalajara,

**Leonel Garcia Benavides, Guillermo Ramos Gallardo**

and every one could be the subject of a textbook.

have "for" and "against" approaches.
