*3.3.8 Osteoprotegerin (OPG)*

A final marker that we have considered for crevicular fluid is osteoprotegerin; this biomarker was studied by Kinney et al. [77]. They studied healthy patients, with gingivitis and periodontitis, finding that the biomarker OPG was elevated in patients with periodontal disease with a significant difference when compared with healthy patients, so they conclude that this biomarker has a good sensitivity to rule out periodontal disease of gingival health.
