**6. Conclusion**

Although there are several studies that associate various candidate gene polymorphisms to periodontitis, till date there is not much clarity in the genetic susceptibility to the disease since there are a multitude of etiological factors and epigenetic factors that contribute to the susceptibility as well as severity of periodontal disease. Future research should focus on the multitude of genes, their multiple interactions and the epigenetic regulation during different stages of periodontal disease pathogenesis is required to fully understand the molecular mechanisms behind the etiopathogenesis of periodontitis.
