**2. FDA and mesotherapy**

The FDA is the association concerning about the assurance of the food and drug safety. Although FDA did not approve the mesotherapy technique, it approved many drugs that have been used in mesotherapy as aminophylline, yohimbine, procaine, lidocaine, and marcaine [7]. Other drugs do not have the FDA approval for any purpose of usage as it is beyond the scope of FDA because they do not consider drugs as vitamins and minerals [8]. It also approved the delivery method using mesogun [1]*.*

All the drugs used in mesotherapy are considered by the FDA as off-label used drugs. The off-label approval includes the approved drug and the approved route of administration of this drug. The local anesthetic agents calcitonin, hyaluronidase, and collagenase are not approved by the FDA [9].
