**5. Conclusions**

Currently, a number of biomarkers have been sought for the detection of periodontal disease, but so far an ideal biomarker has not been found that helps early detection of the disease; perhaps the combination of several is the most appropriate.

The search for biomarkers continues, we suggest for further studies in search of new biomarkers, it should be consider having a larger sample size, a random source and keep a follow-up.
