**Abstract**

The bidirectional relationship between local and systemic pathways makes it difficult to provide a safe intraoral treatment. Nowadays, mesotherapy has become more necessary in dentistry to overcome the huge number of surgical interventions either for therapeutic or for cosmetic purposes. It also limits the need for systemic drugs achieving favorable outcomes with minimal side effects. Further researches are needed to examine the usage of mesotherapy in different oral problems. In dermal mesotherapy, dermatologists used several materials as hyaluronic acid, collagen, hydroxyapatite, carboxymethyl cellulose, and silicone. Such materials exhibit different manners according to their resorption rate: temporary, semipermanent, permanent, and combinations. Furthermore, B-tricalcium phosphate and hydroxyapatite are considered as tissue stimulators by stimulation of collagen formation. Combinations of temporary materials in order to achieve immediate filling effect with tissue stimulator as HA or B-TCP achieve better results.

**Keywords:** oral mesotherapy, intraepidermic injection, minimally invasive techniques, vitamins, tooth traction, depigmentation, connective tissue thickening
