**6. Complications and criticism of mesotherapy**

The main complications reported in this technique include ulceration, bleeding, infections, allergy, abscess, hyperpigmentation, and swelling related to the area to be injected [78, 79]. The main problems of mesotherapy are the lack of training of the practitioner, the difficulty to be evaluated except with biopsy, the inability to diagnose and treat a complication, and the lack of standardized dosage or formulation [1].
