**2.7 Vitamin D**

Vitamin D and Vitamin D receptor are important mediators of bone metabolism. SNPs or dysfunction could lead to bone resorption. The gene encoding vitamin D is located on 12q12-q14.

Gross et al. in their study found that Fok1 polymorphism was associated with periodontitis. Brett et al. in their study found TaqI, BsmI, FokI and ApaI SNPs were associated with periodontitis [18]. Kaarthikeyan et al. did not find any significant association of VDR Taq1 polymorphism with periodontitis in south Indian population [19]. Mashhadiabbas et al. in their meta-analysis based on 38 studies found an association of vitamin D receptor BsmI, TaqI, FokI, and ApaI polymorphisms with periodontitis [20].
