*3.5.1 Proteins (cytokines) involved in the inflammatory process of periodontitis*

Among the cytokines evaluated in plasma, we can say that IL-8 and IL-10 were useful to discriminate patients with aggressive periodontitis from healthy ones, and we can add that they were interleukins different from those expressed in the crevicular fluid where IL-2 and IL-6 were relevant [78].

On the other hand, IFN-γ is a biomarker that has been determined in plasma and was significantly high in patients with aggressive periodontitis, this correlates with the findings in crevicular fluid where this biomarker was elevated in sick patients [78].

Regarding MIP-1α, when it was determined in plasma, it was determined that it could be useful to discriminate patients with aggressive periodontitis from healthy ones, since it was found to be elevated [78].
