*Edited by Robson Faria*

This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.

ISBN 978-1-78984-534-1

Receptors P1 and P2 as Targets for Drug Therapy in Humans

Published in London, UK © 2020 IntechOpen © shellystill / iStock

## Receptors P1 and P2 as Targets for Drug Therapy in Humans

*Edited by Robson Faria*

## Receptors P1 and P2 as Targets for Drug Therapy in Humans

*Edited by Robson Faria*

Published in London, United Kingdom

### *Supporting open minds since 2005*

Receptors P1 and P2 as Targets for Drug Therapy in Humans http://dx.doi.org/10.5772/intechopen.78115 Edited by Robson Faria

Contributors

Luiz A. Alves, Anael V.P. Alberto, Rafael Ferreira, Lucianna H.S. Santos, Dinarte N.M. Ferreira, Xiuxin Liu, Eren Sarikaya, Renato Rozental, Tagore M. Morais-Lima, Joana C. Vicentini, Natiele C. da Silva Ferreira, Pallab Bhattacharya, Deepaneeta Sarmah, Gopika Das, Bharati Sinha, Pedro H.M. de Freitas, Xin Wang, Caio M. Perret, Robson Faria

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#### Notice

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First published in London, United Kingdom, 2020 by IntechOpen IntechOpen is the global imprint of INTECHOPEN LIMITED, registered in England and Wales, registration number: 11086078, 7th floor, 10 Lower Thames Street, London, EC3R 6AF, United Kingdom Printed in Croatia

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Receptors P1 and P2 as Targets for Drug Therapy in Humans Edited by Robson Faria p. cm. Print ISBN 978-1-78984-534-1 Online ISBN 978-1-78984-535-8 eBook (PDF) ISBN 978-1-83880-078-9
