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## Meet the editor

Dr. Ane C.F. Nunes is a geneticist, with her Masters and PhD. in Medical Sciences and Nephrology from the UFRGS/Brazil, and with postdoctoral experience in renal physiology from the UFRJ/ Brazil, clinical medicine and nephrology from the USP/Brazil, and nephrology and hypertension from the UCI/USA. She is a Professor of medical genetics, human genetics and molecular biology. Her research fields are human genetic diseases, cellular

and molecular biology applied to nephrology, biochemistry, and microbiology with projects mainly in the following subjects: inflammatory markers, molecular diagnosis, DNA polymorphisms, chronic kidney disease (CKD), polycystic kidney disease, Fabry disease, rare diseases, cellular and murine models for CKD, RNA processing, fluorescent image analysis, nanoparticles development, and nanomedicine.

Contents

**Section 1**

**Section 2**

Inflammatory Process *by Ane C.F. Nunes*

*and Márcia Guimarães da Silva*

*and Samantha Giordano-Mooga*

*by Uma Ranjan Lal and Inder Pal Singh*

Bowel Disease

**Preface III**

General Aspects of Inflammatory Process and Immune System Network **1**

**Chapter 1 3**

**Chapter 2 7**

Clinical and Pharmacological Approaches **25**

**Chapter 3 27** Pharmacological Challenge Models in Clinical Drug Developmental Programs *by Salma Assil, Robert Rissmann and Martijn Bastiaan Adriaan van Doorn*

**Chapter 4 45**

**Chapter 5 69**

**Chapter 6 101**

*by Sari Terrazas, Lauren Brashear, Anna-Katherine Escoto, Shannon Lynch,* 

*by Maria Angeles Aller, Javier Blanco-Rivero, Ana Arias and Jaime Arias*

Review and Implications of Traditional Indian Medicine for Inflammatory

Introductory Chapter: Overview of the Cellular and Molecular Basis of

Spontaneous Prematurity, Innate Immune System, and Oxidative Stress

at the Maternal-Fetal Interface: An Overview

Sex Differences in Obesity-Induced Inflammation

*Dylan Slaughter, Neena Xavier, Norman Robert Estes II* 

The Wound-Healing Portal Hypertensive Response

*by Natália Prearo Moço, Bruna Ribeiro de Andrade Ramos, Mariana de Castro Silva, Jossimara Polettini, Ramkumar Menon* 

### Contents



Preface

Inflammatory processes, their causes, and parameters are, by themselves, elements of considerable debate in the medical-scientific community. Faced with a wide range of questions and lines of action, it is pertinent to address studies on inflammation using a translational approach. Based on this aspect, the idea of this book

Although this was an arduous task considering the many equally appropriate titles that were submitted, the chapters that follow fulfill this interdisciplinary goal and

Readers will find in these four sections different translational studies about inflam-

(1) General Aspects of Inflammatory Process and Immune System Network: This is the introductory unit and the first chapter presented by me as the Academic Editor summarizes the basis of inflammation and its interactions. An extension of this approach is presented in the second chapter produced by Dr. Guimarães da Silva group, which brings to this book an interest aspect of the ontogenetic effect of the

(2) Clinical and Pharmacological Approaches: Four chapters that link experimental models and clinical information make up this unit. In the first one, Dr. Van Doorn and collaborators report the pharmacological properties of some models used for drug development. The second chapter, which was prepared by the Dr. Giordano-Mooga group, is a comprehensive review on the impact of sex differences over obesity, cardiovascular disease, diabetes, kidney disease, and its links with the inflammatory process. The third chapter by the Dr. Arias group brings to this book a well-detailed review on wound-healing response, with special emphasis on the immunological and ontogenetic features of portal hypertensive inflammation. Closing this section, the fourth chapter is an in-depth presentation produced by Dr. Lal, which features the implications of the traditional Indian System of

(3) Role of Chronic Inflammation in Cancer: Because of its complex network of interactions, cancer itself deserved an entire section to cover its specific inflammatory characteristic. In this book, two comprehensive chapters compose this subject. In the first chapter, Dr. Ziaei describes the process by which chemotherapy compounds act under an inflammatory condition. In the second chapter of this section, Dr. Ran and colleagues reviewed the role of the TLR4 pathway and its intricate

(4) Therapeutic Perspectives for Inflammation: The final section of this book presents three chapters that cover some innovative proposals for inflammation management. Opening this section is the chapter by Dr. Elsayed and Dr. Noreddin. They present an overview of inflammation and nanomedicine. In the second chapter of this section, Dr. Rosemblatt and colleagues review the role of epigenetic processes

molecular panel related to innate immune system and oxidative stress.

Medicine for management of the inflammatory bowel disease.

performance in inflammation and tumor spread.

we selected them based on quality and variety.

mation from different points of view:

grew.
