3.11.1 Leaf extracts

To evaluate the antipyretic activity, different doses (100, 200, and 300 mg/kg body wt. p.o.) of ethanolic leaf extracts showed significant dose-dependent reduction in normal body temperature and yeast-induced elevated temperature (pyrexia) in albino rats. The antipyretic effect of this extract was comparable to that of the standard antipyretic agent paracetamol at 150 mg/kg body wt., p.o. The effect extended up to 5 hours after drug administration compared to that of paracetamol (150 mg/kg.b.wt., p.o.) [2, 6].
