3.17.1 Fruit extracts

Proteases derived from fig aqueous-ethanolic extract were investigated on human blood coagulation using ex vivo model of human platelets from volunteers free of medications for 1 week. Extracts at 0.6 and 1.2 mg/mL repressed the human platelet aggregation with the agonists adrenaline and adenosine 5<sup>0</sup> -diphosphate (ADP). Ficin, a mixture of proteases derived from figs, seems to be responsible for the activation of blood coagulation factor X (vitamin K-dependent plasma glycoprotein with pivotal role in hemostasis) [2, 6, 38].
