**1. Introduction**

The consumption of fresh fruits and vegetables is essential for a healthy diet [1]. However, their production can be affected by microbial pathogens (mostly fungus) during the production chain [2]. In order to reduce the presence of pathogens, several post-harvest technologies have been applied [2]. One of them is the application of chemical fungicides; however, this practice is not accepted due to environmental and health issues [3]. Other alternatives are the use of eco-friendly substances such as generally recognized as safe (GRAS) compounds and emergent technologies like ultrasound and fogging. Currently, consumers demand fresh products free of chemical residues; therefore, it is necessary to develop technologies eco-friendly, effective to protect against pathogens infection, and that these technologies can maintain the fruit quality. Alternative systems such as edible coatings, essential oils, salts, natural compounds (plant extracts), among others to chemical use are suitable approaches for post-harvest disease management. These alternatives can be applied in combination with other control systems like emerging technologies (ultrasound) in order to improve their efficacy. The aim of this chapter is to make a compilation of several studies conducted on fruits for controlling important pathogens in several crops.
