3.9 Irritant potential

### 3.9.1 Leaf extracts

Methanolic leaf extract and isolated triterpenoids [methyl maslinate (127), calotropenyl acetate (130), and lupeol acetate (135)] exhibited irritant potential on open mice ears and were the most potent and persistent irritant effects [2].

## 3.10 Antimicrobial, nematicidal, and anthelmintic activities
