**2.1 Clinical study**

Abnormalities of secretion and metabolism of many steroid hormones occur in DM. In poorly controlled type 1 DM, serum concentrations of DHEA and DHEA-S decrease (Couch,1992) while plasma ACTH and cortisol levels increase in type 2 DM (Hashimoto et al.,1993). Low levels of DHEA and DHEA-S in type 2 DM are associated with hyperinsulinemia(Hubert et al.,1991; Nesler et al.,1989; Schriock et al.,1988; Smith et al.,1987;). We analyzed serum DHEA and DHEA-S levels in poorly controlled type 2 DM.
