**8. Conclusion**

From the data presented it became obviously the strategy for the searching of new medications on the basis of estrogen receptors ligands with the improved properties in comparison with clinically used. As far as the synthesis of such ligand is very complicated task, on the first stage the group with known structure peculiarities in the solution (including conformational dynamics) and determinate the possibilities for theoretical calculations of their spatial structure. The following docking of new possible agents into structures of macromolecule compounds (receptors, enzymes and other proteins) is used for the selection of most perspective compounds. And it is quite necessary to take into account the metabolic ways of new analogues.
