**11. Conclusions**

Taken together the results obtained by different experimental approaches show that the synthesis and release of hormone by the adrenals and ovaries are under multiple controls. The hormonal signals arise from different sources, including the adrenals and ovaries. The adrenal and ovarian innervations modulate the effects of the hormonal signals, possibly by differences in the frequency and amplitude release of different neurotransmitters.

Because the mechanisms regulating the release of steroid hormones changes during the estrous cycle and throughout the day, it is possible that circadian signals arising from the suprachiasmatic nucleus exert a fine modulation of adrenal and ovarian cells to hormone and neural signals (Buijs et al.,2006).

Currently we do not have a clear hypothesis to explain why the organs secreting steroid hormones are asymmetric, or why such asymmetry varies during the estrous cycle and the hour of the day. Questions arising in the intent to present a hypothesis include:

