**Drug Design Approaches to Manipulate the Agonist-Antagonist Equilibrium in Steroid Receptors**

Scott J. Lusher1,6, Paolo Conti2, Wim Dokter3, Pedro H. Hermkens2,4 and Jacob de Vlieg1,5,6 *Departments of 1Molecular Design & Informatics, 2Medicinal Chemistry 3Immune Therapeutics, MSD, Oss 4Institute of Molecules & Materials 5Computational Drug Discovery Group, Radboud University, Nijmegen, 6Netherlands eScience Center, The Netherlands* 
