**Author details**

Peter A. Everts1 \*, Glenn Flanagan II2 , Joshua Rothenberg3 and Kenneth Mautner4

1 Scientific and Educational Division, Gulf Coast Biologics, Fort Myers, FL, USA

2 Naples Regenerative Institute, Regenerative Orthopedics Interventional Spine and Joint, Naples, FL, USA

3 Boca Raton Regional Hospital and Baptist Health South Florida, Regenerative Medicine and Boca Care Orthopedics and Interventional Sports and Spine, Deerfield Beach, FL, USA

4 Emory Sports Medicine and Primary Care Sports Medicine, Emory University, Atlanta, GA, USA

\*Address all correspondence to: peter@gulfcoastbiologics.com

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**31**

*The Rationale of Autologously Prepared Bone Marrow Aspirate Concentrate for use…*

of bone tissue. Medicina Oral, Patología Oral y Cirugía Bucal. 2006;**11**:E47-E51

[9] Kopp H-G, Avecilla ST, Hooper AT, Rafii S. The bone marrow vascular niche: Home of HSC differentiation and mobilization. Physiology.

[10] McDaniel JS, Antebi B, Pilia M, Hurtgen BJ, Belenkiy S, Necsoiu C, et al. Quantitative assessment of optimal bone marrow site for the isolation of porcine mesenchymal stem cells. Stem Cells International. 2017;**2017**:1-10

[11] Gurevitch O, Slavin S, Feldman AG.

Gonçalves-Silva T, Cordeiro-Spinetti E, Galvani RG, Balduino A. A T cell view of the bone marrow. Frontiers in Immunology. 2016;**7**:194. DOI: 10.3389/

Conversion of red bone marrow

[12] Bonomo A, Monteiro AC,

[13] Lambertsen H. Study of the distribution marrow colonies. Blood.

Miyatake H, Sato T, Uno T, Itoh J, et al. Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment. Blood.

[15] Fliedner TM, Graessle D, Paulsen C, Reimers K. Structure and function of bone marrow hemopoiesis: Mechanisms of response to ionizing

Biotherapy & Radiopharmaceuticals.

[16] Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for

[14] Muguruma Y, Yahata T,

2006;**107**(5):1878-1887

radiation exposure. Cancer

2002;**17**(4):405-426

mechanisms. Medical Hypotheses.

into yellow—Cause and

2007;**69**(3):531-536

fimmu.2016.00184

1984;**63**:287-297

2005;**20**(5):349-356

*DOI: http://dx.doi.org/10.5772/intechopen.91310*

[1] Becker AJ, McCulloch EA, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature. 1963;**197**(4866):452-454

[2] Lee EH, Hui JHP. The potential of stem cells in orthopaedic surgery. Journal of Bone and Joint Surgery.

[3] Jing B, Yuan H, Yi-Ru W, Li-Feng L, Jie C, Shao-Ping S, et al. Comparison of human amniotic fluid-derived and umbilical cord Wharton's Jellyderived mesenchymal stromal cells: Characterization and myocardial differentiation capacity: Comparison of human amniotic fluid-derived and umbilical cord Wharton's Jellyderived mesenchymal stromal cells: Characterization and myocardial differentiation capacity. Journal of Geriatric Cardiology. 2012;**9**(2):166-171

[4] Charbord P. Bone marrow mesenchymal stem cells: Historical overview and concepts. Human Gene Therapy. 2010;**21**(9):1045-1056

[5] Caplan AI. Mesenchymal stem cells. Journal of Orthopaedic Research.

[6] Samsonraj RM, Raghunath M, Nurcombe V, Hui JH, van Wijnen AJ, Cool SM. Concise review: Multifaceted

[7] Pittenger MF. Multilineage potential of adult human mesenchymal stem cells.

[8] Hernández-Gil IF-T, Gracia MAA, Jerez B. Physiological bases of bone regeneration I. Histology and physiology

Science. 1999;**284**(5411):143-147

characterization of human mesenchymal stem cells for use in regenerative medicine: Characterization of human mesenchymal stem cells. Stem Cells Translational Medicine.

2017;**6**(12):2173-2185

1991;**9**(5):641-650

2006;**88**(7):11

**References**

*The Rationale of Autologously Prepared Bone Marrow Aspirate Concentrate for use… DOI: http://dx.doi.org/10.5772/intechopen.91310*
