**5. ADSCs' interactions with TFG-β and GDF11 for skin regeneration**

Increasing evidence has implicated ADSCs in maintaining skin homeostasis at a cellular level through cell differentiation and at the paracrine level. The exosomes they secrete respond to the hemostasis of skin microenvironment by releasing the growth factors promoting neo-angiogenesis, cell differentiation, cell proliferation, and migration [11, 16, 90–92].
