Contents


Preface

Regenerative medicine is a promising interdisciplinary field that applies basic principles of engineering and life sciences to repair, replace, or regenerate damaged or lost tissues and organs. Unlike conventional medicine, regenerative medicine uses human cells and other substances to regrow tissues or restore their functions. An important characteristic of regenerative medicine is that its effects, if not permanent, are long lasting. The main aim of regenerative medicine is to use culturing methods to develop techniques and products using the body's own cells for medical treatment. Regenerative medicine combines approaches such as the use of cell-based, cell-free soluble molecules, stem cells from different sources, gene therapy, tissue engineering, reprogramming of cells and, more recently, cell-free regenerative therapies. This book, *Regenerative Medicine*, provides details of recent advancements in regenerative therapies for regenerative medicine applications.

Regenerative medicine therapies have gained significant popularity in recent years and have provided novel therapeutic approaches for a number of diseases. This book examines research in bone marrow aspirates, adipose tissue-derived stem cells and growth differentiation factor 11, platelet-rich plasma, and nanowires for use in regenerative medicine applications. Chapters focus on the use of stem cells (specifically mesenchymal stem cells derived from bone marrow or adipose tissue) and platelet-rich plasma for regenerative purposes. In addition, the book discusses regenerative medicine applications for eyes, skin, musculoskeletal disorders, spinal disorders, critical limb ischemia, and joint degeneration. Further, it covers the role of hypoxic preconditioning as a strategy to enhance the regenerative potential of stem cells. The chapter by Dr. Everts et al., "The Rationale and Roles of Autologous Prepared Bone Marrow Aspirate Concentrate Cells in Regenerative Medicine Applications," highlights the applications of autologous bone marrow-derived concentrate in regenerative medicine. This chapter begins with a brief introduction of stem cells and their different types and addresses the cellular contents of bone marrow tissue, harvesting, and preparation techniques. In addition, this chapter further discusses characteristics of bone marrow-derived mesenchymal stem cells and their applications in musculoskeletal disorders, spinal disorders, chronic

The chapter "Adipose-Derived Stem Cells (ADSCs) and Growth Differentiation Factor 11 (GDF11): Regenerative and Antiaging Capacity for the Skin" by Dr. Mazini et al. describes how ADSCs cross-react with GDF11 to assure dermal fibroblasts' and keratinocytes' proliferation to reverse the aging process. It also discusses the involvement of cell signaling pathways related to GDF11 and TGF-β in balancing cell rejuvenation and cell regeneration as well as skin anatomy, mechanism of skin aging, role of ADSCs in skin rejuvenation, and interactions of ASDCs with TFG-β and GDF11 for skin regeneration. Finally, the chapter presents immunomodulatory effects and antiaging mechanisms of ADSCs with respect to

"Isolation, Activation and Mechanism of Action of Platelet-Rich Plasma and its Applications for Joint Repair" by Dr. Sanchez et al. highlights the importance

wounds, and critical limb ischemia.

TFG- β and GDF11.
