**7. Complications**

The most common complications are muscle weakness leading to atrophy, bone loss, amputations and blindness.

In the case of chronic cutaneous hyperalgesia, there is a local increase in NGF levels. The application of anti-NGF antibodies may be of benefit in treating hyperalgesia in patients with neuropathy and impaired nerve endings. If combined, NGF, NT-3 and glial cell-line derived neurotrophic factor may be sustainable.

In over 90% of human individuals an overall genetic resistance has been noted.
