Meet the editor

Eva Segelov (MBBS, PhD, FRACP) is Professor and Director of Oncology at Monash University and Monash Health, Melbourne, Australia. She is a Medical Oncologist with specialist interest in the diagnosis and management of upper and lower gastrointestinal cancers, particularly colorectal cancer, neuroendocrine tumours and anal cancer. Prof. Segelov is the international lead on the investigation initiated ICECREAM and ASCOLT academic

international trials and is the Australian lead for many others. She has published over 110 articles, expert reviews and book chapters and is a frequently invited speaker at national and international conferences. She is a European Society of Medical Oncology (ESMO) faculty member for the Gastro-intestinal Group and the CUP, Endocrine Tumours and Others Group and Associate Editor of the Journal of Global Oncology (ASCO). Eva is a Board member of the Australasian Gastro-Intestinal Trials Group, Chair of Gastrointestinal Cancer of the Clinical Oncological Society of Australia and co-founder of the international neuroendocrine research collaborative group CommNETS.

**Preface III**

Molecular Classification **1**

**Chapter 1 3**

**Chapter 2 19**

**Chapter 3 35**

Biomarkers **53**

**Chapter 4 55**

**Chapter 5 79**

**Chapter 6 107**

*by Anuratha Sakthianandeswaren, Polly Sabljak, Meg J. Elliott, Michelle Palmieri* 

Current Utility and Future Applications of ctDNA in Colorectal Cancer

Epigenetic Biomarkers and Their Therapeutic Applications in Colorectal

Predictive Biomarkers for Monoclonal Antibody Therapies Targeting EGFR (Cetuximab, Panitumumab) in the Treatment of Metastatic

*by Daphne Day, Sophia Frentzas, Cameron A. Naidu, Eva Segelov* 

*by Antja-Voy Hartley, Matthew Martin and Tao Lu*

Advances in Molecular Subclassification of Colorectal Cancer

*by Rania B. Georges, Hassan Adwan and Martin R. Berger*

BRAF Mutation and Its Importance in Colorectal Cancer

Experimental Results Help Shape the Development of Personalized

**Section 1**

Contents

**Section 2**

*and Maja Green*

Colorectal Cancer

*and Oliver M. Sieber*

Cancer

*by Avani Athauda and Ian Chau*

Medicine in Colorectal Cancer

*by Lee-Jen Luu and Timothy J. Price*
