**Glossary**

*Advances in the Molecular Understanding of Colorectal Cancer*

*Curatively treated CRC (recurrence surveillance and prognostication)*

NCT02842203 Use of ctDNA for Monitoring of Stage III Colorectal Cancer NCT02842203 Circulating Tumour DNA Analysis to Optimise Treatment for

NCT03416478 The Implication of ctDNA in the Recurrence Surveillance of Stage II and III Colorectal Cancer NCT03312374 ctDNA as a Prognostic Marker for Postoperative Relapse in Early

NCT02997241 Colon Cancer Treatment Decisions and Recurrence Predicting (CCTDRP)

NCT03189576 Measuring Molecular Residual Disease in Colorectal Cancer After

NCT03038217 Investigation of the Value of ctDNA in Diagnosis, Treatment, and

NCT03615170 Application of Circulating Tumour DNA Test in the Diagnosis and

NCT02872779 Correlation Between Circulating Tumour Markers Early Variations

NCT02948985 Evaluation of CTCs Combined With Tumour Marker Detection of

NCT02502656 RAS Mutation Testing in the Circulating Blood of Patients With

NCT03227926 Rechallenge With Panitumumab Driven by RAS Dynamic of Resistance (CHRONOS) NCT03259009 RAS Mutations in ctDNA and Anti-EGFR reINTROduction in

NCT03561350 Detect Microsatellite Instability Status in Blood Sample of

Sequencing NCT03594448 Detection of MSI in Circulating Tumour DNA of Colorectal Carcinoma Patients

NCT03517332 Circulating Tumour DNA Exposure in Peripheral Blood NCT02838836 Tumour Cell and DNA Detection in the Blood, Urine and Bone

NCT03027401 Clinical Sequencing of Cancer and Tissue Repository: OncoGenomics

NCT03546569 Tumour Cells, Tumour DNA and Immunological Response in

NCT03284684 Kinetics of Perioperative Circulating DNA in Cancer Surgery (Periop ctDNA) NCT02579278 Circulating Tumour DNA (ctDNA) Rectal Cancer and the

*Currently recruiting and upcoming clinical trials assessing ctDNA in CRC (http://clinicaltrials.gov).*

Colorectal Cancer (COCA-MACS)

Efficacy of Chemotherapy in mCRC

mCRC (RASINTRO) (RASINTRO)

Marrow of Patients With Solid Cancers

Colonic Stent Placement (CISMO)

Metastatic Colorectal Cancer (RASANC)

Patients With Colorectal Cancer (IMPROVE)

and Intermediate Stage Colorectal Cancer

Primary Surgery and Resection of Metastases

Surveillance of Surgically Resectable Colorectal Cancer

Treatment of Patients With Advanced Rectal Cancer

and Clinical Response in First Line Treatment of Metastatic

Advanced Colorectal Cancer Patients by Next-Generation

Relationship to Extramural Venous Invasion (ctDNA Trial)

**Clinical trial identifier Study title**

*mCRC—monitoring during chemotherapy*

*mCRC—RAS testing*

*mCRC—MSI testing*

*Large multi-disease observational studies*

**68**

**Table 2.**

*Other*

*Molecular Understanding of Colorectal Cancer*
