**Author details**

*Advances in the Molecular Understanding of Colorectal Cancer*

HNPCC hereditary non-polyposis colon cancer

hsc70 heat-shock cognate protein 70 kDa IGF2 insulin-like growth factor 2

iNOS inducible nitric oxide synthase

KRAS Kirsten rat sarcoma 2 viral oncogene LAMP2A lysosomal-associated membrane protein 2A

HS3ST2 (3OST2) heparan sulfate-glucosamine 3-sulfotransferase 2

IGFBP3 insulin-like growth factor binding protein 3

MGMT O-6-methylguanine-DNA methyltransferase

PMS2 PMS1 homolog 2, mismatch repair system component

STAT3 signal transducer and activator of transcription 3

TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2

WRN Werner syndrome ATP-dependent helicase

SUV39H1 suppressor of variegation 3–9 homolog 1 TIMP3 tissue inhibitor of metalloproteinases 3

TNF-α tumor necrosis factor alpha UNC5C Unc-5 netrin receptor C Wif-1 WNT inhibitory factor 1

Hnf1b HNF1 homeobox B

IL-6 interleukin 6

KDM lysine demethylase

LOH loss of heterozygosity mCRC metastatic colorectal cancer

MINT Munc-18-interacting

MSH2, 6 MutS protein homolog 2, 6 MSI microsatellite instability MSS microsatellite stable Nat10 N-acetyltransferase 10

p300/CBP p300/CREB-binding protein

PRMT protein arginine methyltransferase PRMT5 protein arginine methyltransferase 5 PTEN phosphatase and tensin homolog RASSF1A ras association domain family member 1 RASSF2A ras association domain family member 2 RUNX3 runt-related transcription factor 3 SAHA suberoylanilide hydroxamic acid SETD1A SET domain-containing protein 1A SFRP1 secreted frizzled related protein 1 SFRP5 secreted frizzled related protein 5 SMYD3 SET and MYND domain containing 3 SOCS1 suppressor of cytokine signaling 1

miRNA microRNA MLH1 mutL homolog 1

NEUROG1 neurogenin 1 nRNA noncoding RNA

p53 or TP53 tumor protein 53 PCDH10 protocadherin 10 PD-1 programmed death-1 PDL-1 programmed death ligand-1

Plks polo-like kinases

SOX17 SRY-Box 17

WNT wingless type

**96**

Antja-Voy Hartley1 , Matthew Martin1 and Tao Lu1,2,3\*

1 Department of Pharmacology and Toxicology, Indiana University School of Medicine, USA

2 Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, USA

3 Department of Medical and Molecular Genetics, Indiana University School of Medicine, USA

\*Address all correspondence to: lut@iupui.edu

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
