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## IntechOpen Book Series Rheumatology Volume 4

Rie Kurose is a rheumatologist and orthopedic surgeon with extensive experience and management skills. She works for Hirosaki Memorial Hospital, Hirosaki, Japan. She acquired her M.D. and Ph.D. after graduating from Niigata University, Niigata, Japan. As a rheumatologist, she has received the honorable award of annual scientific meeting in American College of Rheumatology and is responsible for the Council of the Japan College of

Rheumatology. Currently, she has obtained the Grants-in-Aid for Scientific Research in Japan, and mainly studies basic research on rheumatology.

**Editor of Volume 4: Rie Kurose** Department of Orthopedic Surgery Hirosaki Memorial Hospital, Hirosaki, Japan

**Book Series Editor: Maria Maślińska** National Institute of Geriatrics, Rheumatology and Rehabilitation Early Arthritis Clinic, Warsaw, Poland

### Scope of the Series

This book series presents new concepts of pathogenesis, including genetic, epigenetic determinants and epidemiology of rheumatic diseases. It focuses on current classification criteria, recommendations for the diagnosis and treatment of rheumatic diseases. The goal of the series is to explain various aspects of disorders associated with impaired immune response and autoimmunity processes. It also discusses risk factors associated with the development of autoimmune diseases, as well as latest discoveries and future perspectives of this extremely dynamic field of internal medicine - rheumatology.

Contents

Introductory Chapter: Gout

*by Dewen Yan and Youming Zhang*

*by Rie Kurose*

The Gout *by Narottam Pal*

Patients

**Preface III**

**Chapter 1 1**

**Chapter 2 5**

**Chapter 3 15**

**Chapter 4 33**

**Chapter 5 57** Prophylaxis of Acute Arthritis at Initiation of Urate-Lowering Therapy in Gout

*by Rajit Sahai, Pramod Kumar Sharma, Arup Misra and Siddhartha Dutta*

Pharmacology of the Therapeutic Approaches of Gout

*by MaximEliseev, Maria Chikina and Evgeny Nasonov*

Personalized Medicine of Urate-Lowering Therapy for Gout

### Contents


Preface

Gout is a disease that has a long history and has been known since before the

This book is a compilation of chapters describing gout, management, ongoing research, and new strategies for treating gout. All of these chapters are authoritative

and accomplished discussions that provide novel perspectives on gout topics.

**Rie Kurose**

Hirosaki, Japan

Department of Orthopedic Surgery, Hirosaki Memorial Hospital,

When the uric acid level in blood rises and hyperuricemia persists for a while, urate crystals precipitate in the joints. When these crystals are processed by leukocytes, a gout attack occurs. If the hyperuricemia continues, lifestyle-related diseases such as obesity, arteriosclerosis, and hypertension often develop. Therefore, it is important to treat gouty arthritis, control hyperuricemia, and manage the complications to

Common Era.

improve the lifestyle.
