**Acknowledgements**

This study was supported partly by the National Natural Science Foundation of China (Nos. 81860489, 81760502, 81572353,81372639,81472243,81660495, and 81460423), the Innovation Program of Guangxi Municipal Education Department (Nos. 201204LX674 and 201204LX324), Innovation Program of Guangxi Health Department (No. Z2013781), the Natural Science Foundation of Guangxi (Nos. 2018GXNSFAA281043, 2017GXNSFAA198002, 2017GXNSFGA198002, 2016GXNSFDA380003, 2015GXNSFAA139223, 2013GXNSFAA019251, 2014GXNSFDA118021, and 2014GXNSFAA118144), Research Program of Guangxi "Zhouyue Scholar" (No. 2017–2038), Research Program of Guangxi Specially-invited Expert (No. 2017-6th), the "12th Five-Year Plan" Planning Program of Guangxi Education Science (No. 2015C397), the Innovative Program of Guangxi Graduate Education (No. JGY2015139), Research Program of Guangxi Clinic Research Center of Hepatobiliary Diseases (No.AD17129025), and Open Research Program from Molecular Immunity Study Room Involving in Acute and Severe Diseases in Guangxi Colleges and Universities (Nos. kfkt20160062 and kfkt20160063).

**185**

**Author details**

for Nationalities, Baise, China

1 Department of Pathology, The Affiliated Hospital of Youjiang Medical University

2 Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

\*Address all correspondence to: yangqian2003@126.com

provided the original work is properly cited.

Qian Yang1,2

*Decontamination of Aflatoxin B1*

*DOI: http://dx.doi.org/10.5772/intechopen.88774*

*Decontamination of Aflatoxin B1 DOI: http://dx.doi.org/10.5772/intechopen.88774*

*Aflatoxin B1 Occurrence, Detection and Toxicological Effects*

Among all mycotoxins, the group of aflatoxins has received much attention due to their severe impact on human and animal health. AFB1 is the most potent carcinogenic agent associated with hepatocellular carcinoma. And AFB1 can negatively affect nutrition absorption, growth and development, and immune system function. AFB1 contamination in the food/feed supplies was found in various countries,

particularly in Asia and Africa. A lot of methods to remove or prevent AFB1 contamination, degrade AFB1, or inhibit AFB1 absorption have been developed in the last several decades. The efficiency of aflatoxin decontamination is subject to such factors as food conditions (food constituents, moisture content, pH conditions) and decontamination technologies and conditions. The traditional physical methods for separation or dehulling of the contaminated grains are the simple and safe ways without expensive costs to reduce the dietary exposure to aflatoxins; they can be chosen by anyone or in any area, which makes them the best methods for poor or undeveloped area. Decontamination of aflatoxin is one of the significant challenges for the food industry. The treated food should keep their nutrition values or other important desired qualities, and no residues be left or new contaminates be produced. Either most of the physical and chemical approaches for aflatoxin detoxification might affect the nutritional properties of the foods or be unsafe for human consumption; however, gamma radiation, ozone applications, microwave heating, electron beam, pulsed light, electrolyzed water, and cold plasma showed great potentials for future applications. Recently some inexpensive methods showed good perspectives for reducing aflatoxins in beer and wine factory, which are good choice to be adopted in commercial factory. Biological approaches based on removal or degradation of aflatoxins by bacteria and yeasts are of the promising perspectives, although these practices cannot be currently adopted for foods commercially. While applying these new technologies to make decontamination of aflatoxin, it shall be vital to make clear of the mechanisms of aflatoxin detoxification to determine the practical applications of these approaches in food products, especially concerning their impacts upon the food constituents. Furthermore, combination with traditional and novel technologies shall be also considered to improve the efficiency of decontamination and break through the limitations for specific technologies.

This study was supported partly by the National Natural Science Foundation of China (Nos. 81860489, 81760502, 81572353,81372639,81472243,81660495, and 81460423), the Innovation Program of Guangxi Municipal Education Department (Nos. 201204LX674 and 201204LX324), Innovation Program of Guangxi Health Department (No. Z2013781), the Natural Science Foundation of Guangxi (Nos. 2018GXNSFAA281043, 2017GXNSFAA198002, 2017GXNSFGA198002, 2016GXNSFDA380003, 2015GXNSFAA139223, 2013GXNSFAA019251, 2014GXNSFDA118021, and 2014GXNSFAA118144), Research Program of Guangxi "Zhouyue Scholar" (No. 2017–2038), Research Program of Guangxi Specially-invited Expert (No. 2017-6th), the "12th Five-Year Plan" Planning Program of Guangxi Education Science (No. 2015C397), the Innovative Program of Guangxi Graduate Education (No. JGY2015139), Research Program of Guangxi Clinic Research Center of Hepatobiliary Diseases (No.AD17129025), and Open Research Program from Molecular Immunity Study Room Involving in Acute and Severe Diseases in Guangxi Colleges and Universities (Nos. kfkt20160062 and

**7. Conclusion**

**184**

kfkt20160063).

**Acknowledgements**
