**Author details**

Qun-Ying Su1,2

*Aflatoxin B1 Occurrence, Detection and Toxicological Effects*

hepatocellular carcinogenesis.

kfkt20160062 and kfkt20160063).

hepatocellular carcinoma (HCC) Aspergillus flavus (*A. flavus*)

Aspergillus parasiticus (*A. parasiticus*)

Nucleic Acid Excision Repair Pathway (NER)

World Health Organization (WHO)

AFB1-8-9-epoxide (AFBO)

European Union (EU)

**Abbreviations**

Aflatoxin B1 (AFB1)

**Conflicts of interest and source of funding**

characterized to lead to the development of hepatocellular carcinoma in humans and animals. The contamination of the food chain by AFB1 has a huge impact on human health and economic damage worldwide. The prevention and detoxification strategies of AFB1 have always been the goal of research. Although physical and chemical treatment is currently the main detoxification method, it is easy to lead to the loss of food nutrition. Biotherapeutics is a relatively new detoxification method. Natural plant extracts and plant essential oils are simple to produce, biosafe, and provide an excellent source of toxin detoxification. Studies have shown that individuals' susceptibility, such as genetic polymorphisms in DNA repair genes and/or metabolic genes, play a huge role in the different detoxification and the repair of DNA damage caused by AFB1. Thus, the biofunction supplementary methods which base on this kind of genetic difference may be not only regarded as potential new detoxification methods but served as potential biological markers for predicting the occurrence of such liver diseases as liver damage, liver cirrhosis, and

The authors declare no competing financial interests. This study was supported in part by the National Natural Science Foundation of China (Nos. 81,860,489, 81,760,502, 81,572,353, and 81,660,495), the Natural Science

Foundation of Guangxi (Nos. 2018GXNSFAA281043, 2017GXNSFAA198002 and 2017GXNSFGA198002), Research Program of Guangxi "Zhouyue Scholar" (No. 2017-2038), Research Program of Guangxi Specially-invited Expert (No. 2017-6th), the '12th Five' Planning Program of Guangxi Education Science (No. 2015C397), the Innovative Program of Guangxi Graduate Education (No. JGY2015139), Research Program of Guangxi Clinic Research Center of Hepatobiliary Diseases (No.

AD17129025), and Open Research Program from Molecular Immunity Study Room Involving in Acute & Severe Diseases in Guangxi Colleges and Universities (Nos.

The Food and Agriculture Organization of the United Nations (FAO)

xeroderma pigmentosum C (XPC),xeroderma pigmentosum D (XPD)

**200**

1 Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China

2 The Centre of Pathology Diagnosis and Research, Youjiang Medical University for Nationalities, Baise, China

\*Address all correspondence to: 155373033@qq.com

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