**4.1 Antioxidants**

First damage in the acute phase of injury is generated in membranes, membranes which are susceptible to the attack of ROS and reactive nitrogen species (RNS). ROS are produced in metabolic and physiological processes of cells; however, they are overproduced by inflammatory response. ROS and RNS induce LPO, which leads to demyelinating processes. Among the nonpharmacological therapies to prevent damage from FR are nonenzymatic antioxidants like vitamins.
