Meet the editors

Dr. Matilde Otero-Losada graduated from the School of Pharmacy and Biochemistry, University of Buenos Aires (UBA), Argentina. She obtained a SciD in Neuropharmacology from the same univeristy and completed a PhD in Psychiatry at Wolverhampton University, England. Her following studies in psychometrics and statistical methods, radioisotopes and radiochemistry, and signal processing and microcomputers, took her to the Univer-

sity of California San Diego (UCSD) for training in human psychophysics. Back to Argentina, she carried on studying smell, taste, and trigeminal perception at the Hospital de Clínicas, UBA. She is devoted to the diagnosis, counseling, support, and treatment of people with olfactory and neurocognitive disorders. Focused on the study of metabolic syndrome, soft drinks, and cardiovascular-renal morbidity for the last ten years, in the last two years she is back to her roots in neuroscience. Dr. Otero-Losada has published more than ninety 90 papers in prestigious, indexed journals and authored several book chapters. She is a senior researcher at the National Research Council (Argentina) and a reviewer and praised editor of books and scientific journals, acknowledged for her stylish writing and editing skills.

Dr. Francisco Capani graduated from the School of Medicine, University of Buenos Aires (UBA), Argentina, and completed his doctoral studies in Neuroscience at the Institute of Cell Biology and Neuroscience "Prof. E. De Robertis," School of Medicine (UBA), Argentina. He completed his postdoctoral studies abroad at the University of California San Diego (UCSD-NCMIR) and the Karolinska Institute, Department of Neuroscience. Over an eight-year period,

his research focused on synaptic organization, combining electron tomography, 3D reconstruction, and correlative light and electron microscopy techniques. Upon his return to Argentina in 2006, he devoted his study to the mechanisms involved in the pathophysiology of the perinatal asphyxia supported by his broad experience in electron microscopy. Dr. Capani has published 115 papers in recognized journals and has been an invited speaker at several international conferences.

Santiago Perez-Lloret is a leading expert in neurophysiology and neuropharmacology with more 100 papers published in international medical journals (H-index = 34). He has recently edited the book *Clinical Trials in Parkinson's Disease*. After obtaining his MD and PhD, he pursued master courses in pharmacoepidemiology, clinical pharmacology, and biostatistics at the Universities of Bordeaux and Paris. Dr. Perez-Lloret is Assistant Professor of

Neurophysiology at the University of Buenos Aires, and a senior researcher at the National Research Council. He is also an associate editor for *Frontiers in Pharmacology*. He is a member of the Education Committee of the International Parkinson's Disease and Movement Disorder Society (MDS).

Contents

**Section 1**

Alzheimer's Disease

**Preface XIII**

Neuroprotection in Alzheimer's and Parkinson's Diseases **1**

**Chapter 1 3**

**Chapter 2 17**

**Chapter 3 37**

**Chapter 4 69**

**Chapter 5 89**

**Chapter 6 105**

Neuroprotective Properties of Cannabinoids in Cellular and

An Alternate View of Neuroprotection with Peptides in

Extracts and Essential Oils from Medicinal Plants and

*Dayane Pessoa de Araújo, Amália Cinthia Meneses do Rego,* 

Glycodendrimers as Potential Multitalented Therapeutics in

Alzheimer's Disease Neuroprotection: Associated Receptors

*by Lucas D. Udovin, Andrea Aguilar, Tamara Kobiec, María I. Herrera, Santiago Perez Lloret, Nicolás Toro Urrego and Rodolfo A. Kölliker Frers*

Polyphenols as Potential Therapeutic Drugs in Neurodegeneration *by Patrizia Polverino de Laureto, Luana Palazzi and Laura Acquasaliente*

*by Ianara Mendonça da Costa, Elaine Cristina Gurgel Andrade Pedrosa, Ana Paula de Carvalho Bezerra, Luciana Cristina Borges Fernandes, José Rodolfo Lopes de Paiva Cavalcanti, Marco Aurélio Moura Freire,* 

*Irami Araujo Filho, Francisco Irochima Pinheiro and Fausto Pierdoná Guzen*

Animal Models: Hypotheses and Facts

*by Samuel King and Cenk Suphioglu*

Their Neuroprotective Effect

Alzheimer's Disease *by Oxana Klementieva*

*by Alice Barros Câmara*
