**1. Introduction**

Soon after discovery of ferrocene in 1951 [1], the main focus of scientists was to determine its accurate structure. Its correct elucidation was carried out individually by Fischer and Hafner and Wilkinson et al. [2, 3]. Woodward et al. termed this ironcontaining compound as ferrocene due to resemblance of its reactivity with benzene [4]. The structural determination of ferrocene proved a revolutionary discovery and a progressive revelation in the historical backdrop of chemistry which directed new dimensions in organometallic chemistry. Today, terms like metallocenes and sandwich compounds are used for ferrocene and ferrocenyl derivatives due to significantly more extensive scope of these compounds that assimilate other metals also [5].

Due to impressive stability of ferrocene in aerobic medium and water, its promising electrochemical properties and openness of an extensive assortment of subordinates have made ferrocenyl derivative compounds widespread molecules for biological applicabilities [6–8]. The promising applications of ferrocene in the field of medicine proved a vigorous research area nowadays [9]. Many reports have revealed that some ferrocenyl derivatives are extremely active in vivo and in vitro,

against various diseases, for example, bacterial and fungal contagions [10, 11], malaria [12], cancer [13], and human immunodeficiency virus (HIV) [14].
