Meet the editors

Dr. Venketeshwer Rao, Professor Emeritus, Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, has established a major focus in the area of diet and health. His research focuses on the role of phytochemicals in the prevention and management of human diseases including cancer, cardiovascular disease, and osteoporosis. The main area of his research is oxidative stress and antioxidant phytochemicals with particular

emphasis on the role of lycopene. He is credited for bringing international awareness to the role of lycopene in human health. In addition to carotenoids, his research interests also include plant polyphenols and the role of prebiotics and probiotics in human health. He has published extensively including research papers, reviews, and books. He has a distinguished academic career spanning over 52 years. He is popularly sought by the international media to express his opinions on the subjects of nutrition and health.

Dennis R.A. Mans (October 16, 1955, Paramaribo, Suriname) graduated as a Medical Biologist in 1984 at the Utrecht University, The Netherlands. He received his PhD diploma in 1991 from the Free University of Amsterdam, The Netherlands, with a thesis on the antineoplastic agent etoposide. Between 1992 and 2000, he worked in Brazil on plants with anticancer properties. He returned to Suriname in 2000 to hold an academic position at

the Anton de Kom University. In 2001, he became Head of the Department of Pharmacology, in 2006 he was appointed Associate Professor, and in 2008 Full Professor with a chair in Pharmacognosy. His scientific production amounts to more than 100 full papers and more than 200 scientific abstracts.

Dr. Leticia Rao is an Emerita Associate Professor of Medicine and former Director of the Calcium Research Laboratory, Department of Medicine, and St Michael's Hospital, Toronto, Ontario. Her degrees include BSc Chemistry, University of the Philippines; MSc Food Science, Oregon State University; and Ph.D. Biochemistry, University of Toronto. Her area of expertise is bone cell biology and osteoporosis with an emphasis on effects

of drugs and nutritional supplements. She has studied the effect of gravity on bone formation in osteoblast cells in an experiment sent to space with the Space Shuttle Columbia STS 107. Her research has been presented to national and international symposia and published in peer-reviewed scientific journals. She co-authored a book entitled "Bone Building Solution" and co-edited a book on phytochemicals.

Contents

**Section 1**

Their Bioactivities

*and Sariya Mapoung*

and Identification

Region (Caatinga)

**Section 2**

*by Robbert Bipat*

*Firdaus and Setiyo Gunawan*

*and Stephen Rathinaraj Benjamin*

One-Pot Synthesis of Coumarin Derivatives

*by Gabriela Tataringa and Ana Maria Zbancioc*

*by Inul Ansary and Abu Taher*

**Preface III**

Phytochemical Composition **1**

**Chapter 1 3**

**Chapter 2 27**

**Chapter 3 45**

**Chapter 4 73**

Coumarins: Bioactivity, Synthesis and Labelling **89**

**Chapter 5 91** From Rat Poison to Medicine: Medical Applications of Coumarin Derivatives

**Chapter 6 105**

**Chapter 7 139**

Coumarin Derivatives with Antimicrobial and Antioxidant Activities

The Phytochemical Composition of Medicinal Plants: Brazilian Semi-Arid

*by Iago Almeida da Ponte, Murugan Muthuvel, Sudarsini Saravanabhavan* 

*by David Febrilliant Susanto, Hakun Wirawasista Aparamarta, Arief Widjaja,* 

Anthocyanins and Proanthocyanidins in Natural Pigmented Rice and

*by Pornngarm Limtrakul (Dejkriengkraikul), Warathit Semmarath* 

*Calophyllum inophyllum*: Beneficial Phytochemicals, Their Uses,

Analytical Methods of Isolation and Identification *by Weisheng Feng, Meng Li, Zhiyou Hao and Jingke Zhang*
