**Abstract**

*Calophyllum inophyllum* Linn. is one type of mangrove plant. This plant is commonly called nyamplung. This plant is abundant in Indonesia and has many properties that can be exploited from the roots, stems, and leaves to the seeds. All parts of this plant can be useful for human needs. Its oil is generally only used as biodiesel feedstock. The aim of this chapter is to discuss the identification and the uses of phytochemicals contained in *C. inophyllum* leaves. There are various kinds of phytochemicals contained in *C. inophyllum* leaves, such as triterpenoids, steroids, flavonoids, coumarins, xanthones, fatty acids, esters, alkenes, ethers, and alicyclic compounds. They have benefits to health, such as anticancer, anti-HIV, antiviral, antitumor, antiinflammatory, antimicrobial, antineoplastic, antiplatelet, antipsychotics, antioxidant, antiaging, antileukemic, antimalarial, anticoagulant, antifeedant, analgesic, photoprotective, molluscicidal, and piscicidal agents. Extraction is a famous method for isolating phytochemicals in *C. inophyllum* leaves, based on the solvent polarity index.

**Keywords:** *C. inophyllum*, human health, identification, isolation, phytochemicals
