Author details

7. Conclusion

Molecular Docking and Molecular Dynamics

selective COX-2 inhibitor.

Acknowledgments

Conflict of interests

58

Exploration of sesquiterpenoid/sesquiterpenoid alcohol compounds as inhibitors of COX isoenzymes as development of group NSAIDs, was carried out by means of in silico tools. The binding energy calculation (using PBSA Model Solvent) of sesquiterpenoid/sesquiterpenoid alcohol compounds: alpha patchouli alcohol (CID521903) and seychellene (CID519743) were identified as the candidates of non-selective inhibitor; alpha bulnesene (CID94275), alpha guaiene (CID107152), and alpha-patchouli alcohol isomers (CID6432585, CID3080622, CID10955174, while CID56928117) had been suggested as the candidate for a selective COX-1 inhibitor. Whereas, alpha-patchouli alcohol (CID442384) was the candidate for a

This study was supported by Doctoral program scholarship of "Sandwich-Like

acknowledge all facilities of Bioinformatics Laboratory Department of Creation Core, Ritsumeikan University, for providing the in silico analyses. Special thanks are due to Prof. Takhesi Kikuchi (my sensei), Masanari Matsuoka, Antonius Christianto, Michirou Kabata, Sayaka Ohara, Yousuke Kawai, and working group Bioinformatic Laboratory, Biwako Kutsasu Campus, Ritsumeikan University, for helpful support analysis and discussions. And also my wife (Sri Wahjoeni), my son (Damara Setyowijayanto Raharjo), Prof. Fatchiyah, Prof. Chanif Mahdi, Prof. Sutiman, Dr. Nurdiana, Lectures of Biology Dept. Brawijaya University, Lectures Academic of Pharmacy and Food Analysis "Putra Indonesia Malang", Yayasan Putera Indonesia

Program 2013," DGHE, Ministry of Education and Culture, RI. The authors

Malang, and Pharmacy Dept. Faculty Medicine Brawijaya University.

The authors declare no conflict of interests.

Sentot Joko Raharjo Academic of Pharmacy and Food Analysis "Putra Indonesia Malang", Malang, Indonesia

\*Address all correspondence to: sjraharjo.akafarma@pimedu.ac.id; sjraharjo03@gmail.com

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
