7. Conclusion

Exploration of sesquiterpenoid/sesquiterpenoid alcohol compounds as inhibitors of COX isoenzymes as development of group NSAIDs, was carried out by means of in silico tools. The binding energy calculation (using PBSA Model Solvent) of sesquiterpenoid/sesquiterpenoid alcohol compounds: alpha patchouli alcohol (CID521903) and seychellene (CID519743) were identified as the candidates of non-selective inhibitor; alpha bulnesene (CID94275), alpha guaiene (CID107152), and alpha-patchouli alcohol isomers (CID6432585, CID3080622, CID10955174, while CID56928117) had been suggested as the candidate for a selective COX-1 inhibitor. Whereas, alpha-patchouli alcohol (CID442384) was the candidate for a selective COX-2 inhibitor.
