**8.1 Tourette syndrome**

Due to the behavioral and cognitive issues in these patients, less than 300 patients have endured DBS treatment across the world. Patients with chronic symptoms are improved less than those with mild symptoms as per a meta-analysis [64]. A randomized controlled trial in 2017 did not report any significant improvement of tics in Tourette syndrome patients treated with anteromedial GPi stimulation during the initial blinded phase of the study; however, tics improvement was documented during the study's transparent period [65]. There is need of more randomized control trials for further development of DBS treatment in these patients.
