**10. References**


An Integrative Review of Estradiol Effects on Dendritic Spines and Memory over the Lifespan 195

Leranth C, Petnehazy O, MacLusky NJ. (2003). Gonadal hormones affect spine synaptic density in the CA1 hippocampal subfield of male rats. J Neurosci. 23: 1588-92. Leuner B, Falduto J, Shors TJ. (2003) Associative memory formation increases the observation of dendritic spines in the hippocampus. J Neurosci. 23(2):659-65. Leuner B, Gould E. (2010) Dendritic growth in medial prefrontal cortex and cognitive

Li, C, Brake, WG, Romeo, RD, Dunlop, J.C., Gordon, M, Buzescu, R, Magarinos, A, Allen, P,

Luine, V and Hearns, M Spatial memory deficits in aged rats: Contributions of the cholinergic system assessed by ChAT. Brain Research 523: 321-324 (1990). Luine, V, Attalla, S, Mohan, G, Costa, A and Frankfurt, M (2006). Dietary phytoestrogens

Luine, VN. (2008). Sex steroids and cognitive function. J. Neuroendocrinology 20: 866-72. Luine, VN, Jacome, L F and MacLusky, NJ., (2003). Rapid enhancements of visual and place

Macbeth AH, Luine VN (2010) Changes in anxiety and cognition due to reproductive

Macbeth AH, Scharfman HE, MacLusky NJ, Gautreaux C, Luine VN (2008) Effects of

MacLusky, NJ, Luine, VN, Hajszan, T, Prange-Kiel and Leranth C. (2005). The 17 and

Markham, JA, McKian, KP, Stroup, TS, Juraska, JM (2005) Sexually dimorphic aging of dendritic morphology in CA1 of hippocampus. Hippocampus 15, 97-103. Markowska, AL (1999) Sex dimorphisms in the rate of age-related decline in spatial memory: relevance to alterations in the estrous cycle. J. Neurosci. 19, 8122-8133. McLaughlin, KJ, H Bimonte-Nelson, JL Neisewander, CD Conrad (2008). Assessment of

derived neurotrophic factor (BDNF). Hormones & Behavior 54 7-17. Macbeth, AH, Gautreaux, C and Luine, VN (2008). Pregnant rats show enhanced spatial

memory tasks in female mice Proc. Nat'l Acad. Science 101: 2185-2190. Luine, V.N., Wallace, M. Frankfurt, M. (2011). Age-related deficits in spatial memory and

Geriatric Research. 2011:316386. Epub 2011 Aug 18.

Biobehavioral Reviews. 34, 452-467.

neurotransmitters. Brain Research 1241:136-47.

cingulated cortex. Neurobiol Aging 23, 579-588.

in altering CA1 spines. Hormones & Behavior 54: 386-395.

cortex of ovariectomized rats. Brain Research 1126: 183-187.

memory by estrogens in rats. Endocrinology 144 (7), 2836-2844.

Horm Behav 49(2):131-42.

of pregnancy modify concentrations of hippocampal neuronal dendritic spines.

flexibility are enhanced during the postpartum period. J Neurosci. 2010 30:13499-503.

Greengard, P. Luine, V, and McEwen, BS. (2004).Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial

hippocampal spines in virgin, female, Fischer-344 rats. Current Gerontology and

enhance spatial memory and spine density in the hippocampus and prefrontal

experience: a review of data from rodent and human mothers. Neuroscience &

multiparity on recognition memory, monoaminergic neurotransmitters, and brain-

memory, decreased anxiety, and altered levels of monoaminergic

isomers of estradiol both induce rapid spine synapse formation in the CA1 hippocampal subfield of ovariectomized female rats. Endocrinology 146: 287-293. Markham JA, Juraska JM. (2002) Aging and sex influence the anatomy of the rat anterior

estradiol influence on spatial tasks and hippocampal CA1 spines: Evidence that the duration of hormone deprivation after ovariectomy compromises 17β-effectiveness


Bimonte HA, Nelson ME, Granholm AE (2003). Age-related deficits as working memory load increases: relationships with growth factors. Neurobiol Aging 24, 37-48. Bowman, RE, Beck, KD and Luine, VN (2003) Chronic stress effects on memory: Sex differences in performance and monoamines. Hormones and Behavior 43: 48-59. Bourne JN, Harris KM (2008) Balancing structure and function at hippocampal dendritic

Broadbent, N, Squire, L and Clark, R (2004). Spatial memory, recognition memory, and the

Brusco J, Wittmann R, de Azevedo MS, Lucion AB, Franci CR, Giovenardi M, Rasia-Filho

Dohanich, GP (2002) Gonadal Steroids, learning and memory In: Pfaff DW, Arnold AP,

Ennaceur, A, Neave, N and Aggleton, J (1997). Spontaneous object recognition and object

Fortin DA, Srivastava T, Soderling TR (2011) Structural Modulation of Dendritic Spines during Synaptic Plasticity. Neuroscientist. 2011 Jun 13. [Epub ahead of print] Frankfurt, M, Salas-Ramirez, K., Friedman, E. and Luine, VN (2011). Cocaine alters dendritic

Frick, KM, Fernandez, SM, Bennett JC, Prange-Kiel J, MacLusky NJ and Leranth C (2004)

Frick KM (2008) Estrogens and age-related memory decline in rodents: what have we

Gould E, Woolley CS, Frankfurt, M, McEwen, BS. (1990). Gonadal steroids regulate

Hotulainen P and Hoogenraad, CC (2010) Actin in dendritic spines: connecting dynamics to

Jacome, LF, Gautreaux, C, Inagaki, T, Mohan, G, Arellanos, A., MacLusky, N., Alves, S.,

Jedlicka P, Vlachos A, Schwarzacher SW, Deller T (2008) A role for the spine apparatus

Kinsley CH, Trainer R, Stafisso-Sandoz G, Quadros P, Marcus LK, Hearon C, Meyer EA,

in LTP and spatial learning. Behav Brain Res. 192(1):12-9. Kinsley, CH (2008). The neuroplastic maternal brain. Horm Behav. 55, 1-4.

virgin and postpartum female rats. Neurosci Lett 438(3):346-50.

AA. (2008). Plasma hormonal profiles and dendritic spine density and morphology in the hippocampal CA1 stratum radiatum, evidenced by light microscopy, of

Etgen AM, Fahrbach SE, Rubin RI, eds. Hormones, Brain and Behavior. San Diego,

location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix. Exp. Brain Research 113,

spine density in cortical and subcortical regions of the postpartum and virgin

Behavioral training interferes with the ability of gonadal hormones to increase CA1 spine synapse density in ovariectomized female rats. European J. Neuroscience 19:

learned and where do we go from here? Horm Behav. 55 2-23.Frye, CA, Duffy, CK, Walf, AA (2007). Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task. Neurobiol. Learn Mem.88, 208-16.

dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci

Lubbers, L and Luine, VN. (2010). ER Agonists Enhance Recognition Memory and Alter Monoamines in Ovariectomized Rats. Neurobiology of Learning and

Hester N, Morgan M, Kozub FJ, Lambert KG. 2006. Motherhood and the hormones

spines. Annu Rev Neurosci. 31:47-67.

CA: Academic Press, 2002: 265-327.

female rat. Synapse 65: 955-61. .

function J Cell Biol. 189(4):619-29.

Memory 94: 488-98 PMC 2975833.

509-519.

3026-32.

10:1286–1291.

hippocampus. PNAS 101 (40), 14515-14520.

of pregnancy modify concentrations of hippocampal neuronal dendritic spines. Horm Behav 49(2):131-42.


**Part 3** 

**Sex Steroids and the Immune Response** 

