**3.1 Prevalence of obesity**

In our recent study of 18 girls with CPP or early puberty, five girls (27.8%) were diagnosed with obesity because their BMI values were higher than the 95th centile (Inokuchi, 2009) at the initiation of therapy. Moreover, the BMI standard deviation score (SDS) for chronological age (CA) was higher than zero in 14 (77.8%) patients, and the mean BMI SDS for CA was 1.07±0.32 at the baseline. Even when it was corrected for bone age (BA), the BMI SDS was still higher than zero in 9 (50.0%) patients, and the mean BMI SDS was 0.33±0.25 at the baseline. On the other hand, the POW was higher than 20% (indicating obesity) in 5 patients (27.8%) at the baseline.
