**Chapter 3**

*Monoclonal Antibodies*

10.1155/2020/3038564.

Schots A, Steinkellner H.

[98] Nessa MU, Rahman MA, Kabir Y. Plant-Produced Monoclonal Antibody as Immunotherapy for Cancer. Biomed Res Int. 2020 Aug 24;2020:3038564. doi: [106] Clinical Trials. Available from: https://clinicaltrials.gov/ct2/show/ NCT03301051?term=medicago

[107] Lim S, Kim DS, Ko K. Expression of a Large Single-Chain 13F6 Antibody with Binding Activity against Ebola Virus-Like Particles in a Plant System. Int J Mol Sci. 2020 Sep. 23;21(19):7007.

[Accessed: 2020-11-09]

doi: 10.3390/ijms21197007.

[108] Zahara K, Bibi Y, Ajmal M, Sadaf HM, Bibi F, Sardar N, Laraib S, Riaz I. Tobacco plant: A possible key to Ebola vaccine. Jclm. 2017 May 5(5) 206:211 doi: /10.12980/jclm.5.2017J7-9.

[99] Bosch D, Castilho A, Loos A,

N-glycosylation of plant-produced recombinant proteins. Curr Pharm Des. 2013;19(31):5503-5512. doi: 10.2174/1381612811319310006.

[100] Jin C, Altmann F, Strasser R, Mach L, Schähs M, Kunert R,

immune response in rabbits.

doi: 10.1093/glycob/cwm137.

[101] Strasser R, Altmann F,

copbio.2014.06.008.

s10529-019-02651-z.

10.1038/342076a0.

s10529-015-1908-z.

[104] Hiatt A, Cafferkey R,

in transgenic plants. Nature. 1989 Nov 2;342(6245):76-78. doi:

of plant-produced recombinant proteins. Curr Opin Biotechnol. 2014 Dec;30:95-100. doi: 10.1016/j.

[102] Castilho A, Steinkellner H. Glyco-engineering in plants to produce human-like N-glycan structures. Biotechnol J. 2012 Sep;7(9):1088-1098.

doi: 10.1002/biot.201200032.

[103] Donini M, Marusic C. Current state-of-the-art in plant-based antibody production systems. Biotechnol Lett. 2019 Mar;41(3):335-346. doi: 10.1007/

Bowdish K. Production of antibodies

[105] Mor TS. Molecular pharming's foot in the FDA's door: Protalix's

trailblazing story. Biotechnol Lett. 2015 Nov;37(11):2147-2150. doi: 10.1007/

Rademacher T, Glössl J, Steinkellner H. A plant-derived human monoclonal antibody induces an anti-carbohydrate

Glycobiology. 2008 Mar;18(3):235-241.

Steinkellner H. Controlled glycosylation

**42**
