Contents


Preface

Immunology science has made prominent progress in recent years, helping in all medical fields from diagnosis to treatment. Nowadays, immunotherapy procedures are used in the treatment of a variety of autoimmune diseases, cancers, and organ transplants. It has also paved the way for medical researchers toward a promising future in the treatment of immunological disorders. Immune-based therapies are widely explored in several immunological disorders due to their high specificity and sensitivity. Since the approval of the first monoclonal antibody (mAb) in 1986, mAbs have been used as a novel way of targeting antigens in these disorders. Currently, mAbs are an important group of therapeutic molecules in clinical trials for treating disorders such as inflammatory and autoimmune diseases, malignancies, and

This book provides knowledge about several types of mAbs and their application in the clinic and laboratory. The introduction describes mAbs, their structure, and their production process. Subsequent chapters cover more information about the therapeutic application of mAbs, especially in urology and oncology and for multiple myeloma. Furthermore, the book discusses the production and characterization of mAbs. In this regard, chapters examine alternative methods to animal use for generating mAbs as well as novel analytical and *in silico* techniques for characterizing them. These methods can provide comprehensive information about technologies

The book describes and discusses immunology concepts and mechanisms related to the function of mAbs in a clear and simple way, making the information herein

**Nima Rezaei, MD, Ph.D.**

Children's Medical Center,

Tehran, Iran

Tehran, Iran

Research Center for Immunodeficiencies,

Universal Scientific Education and Research Network (USERN),

Tehran University of Medical Sciences,

Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA),

cardiovascular and infectious diseases.

associated with mAb production.

useful for scientists and clinicians in various fields.
