**1. Introduction**

This chapter will review our current state of the art knowledge about bulgecins, natural inhibitors of lytic transgylcosylase cell wall enzymes, and their activity as β-lactam enhancers to inhibit growth of *P. aeruginosa*. Current known resistance mechanisms targeting β-lactams in *P. aeruginosa* be reviewed, followed by an introduction to the lytic transglycosylases of *P. aeruginosa*. The use of bulgecins as adjunctive agents with β-lactams will be described as well as the synthesis of Bulgecin A, the most active of these compounds.
