**Abstract**

*Pseudomonas aeruginosa* is an opportunistic bacterium that can proliferate in the soil, water, and even humans if they are immunologically depressed. During lung infections, *P. aeruginosa* goes through significant morphological changes turning into the mucoid form after which its eradication becomes almost impossible. Within this chapter, we explore the bioenergetics changes produced within *P. aeruginosa* during infections in humans and the metabolic pathways that are involved in those changes that lead to chronic infection.

**Keywords:** *P. aeruginosa*, host, bioenergetics, phosphate, choline
