**Abstract**

*Pseudomonas aeruginosa* is considered as the most potent bacterial strain for solving heavy metals pollution problems. Pollution is the most of problems in our world which causing a lot of risks to human, animal, plant and ecosystem. Heavy metals pollution is an ever-increasing problem in developing nations. Release of heavy metals into the environment has increased in the recent years at an alarming rate. To remove heavy metals from environment, there are different methods such as physical, chemical and biological. The biological method includes microorganisms and plant which recorded high heavy metals removal, safe and low-cost method. Microorganisms remove heavy metals from environment by different mechanisms according to their types. Thus, microbes are used as potential candidates of bioremediation that can adapt quickly to the changing noxious environment and be utilized for toxic metal remediation. In bacterial uptake and tolerance to heavy metals, *Pseudomonas aeruginosa* recorded potential role in bioremediation of different heavy metals with high removal percentage comparison with other bacterial strains. Chapter discusses the roles and trends of *Pseudomonas aeruginosa* in heavy metals tolerance and uptake as potential bacterial strain.

**Keywords:** pollution, *Pseudomonas aeruginosa*, heavy metals, bioremediation, tolerance, plasmid and resistant genes
