**Abstract**

Currently, metabolic diseases are the main public health problem. Obesity is a metabolic imbalance that leads to insulin resistance, hyperinsulinemia, dyslipidemia, hypertension, and proinflammatory and prothrombotic states that can trigger type 2 diabetes as well as cardiovascular diseases. Obesity is the excess of adipose tissue and is considered a risk factor to develop metabolic syndrome. The obesogenic environment that is lived promotes the search for specific solutions that help to control, eradicate, or minimize the negative results in health, making use of the properties of flavonoids, as important sources of antioxidants, with anti-inflammatory, antithrombotic, and antihypertensive effects. Given the above, the objective of this chapter is to highlight the effects of flavonoids on the modulation of lipolysis and lipogenesis altered by a hyperlipidic diet.

**Keywords:** flavonoids, lipolysis, lipogenesis, obesity, inflammation
