**2.2 Pro- and anti-angiogenic capacity of exosomes**

It was shown that a significant portion of MSC angio-activity drives from their potency to release exosomes that can affect the function of ECs, either by increasing the production of pro-angiogenic factors or decreasing the production of anti-angiogenic factors [91]. The fact that MSC exosomes promote angiogenesis, by delivering mediators such as miRNAs, protein factors to distinct cells, was confirmed in various in vivo experimental studies [89, 92, 93].
