9. MSCs in fungal infections

Administration of human MSCs does not have negative impact on host response against Aspergillus fumigatus [118, 119]. Also, Aspergillus fumigatus does not stimulate MSCs to secrete cytokines that play a major role in the pathogenesis of GVHD indicating that Aspergillus fumigatus is not involved in the pathogenesis of GVHD following HSCT. In an animal model, infusion of BM-MSCs into mice infected with Paracoccidioides brasiliensis failed to induce any antimicrobial effects.
