*4.2.1 Corneal angiogenesis assay*

The cornea is considered as avascular tissue with unique properties for monitoring the angiogenesis and done in the model of mouse, rat, and rabbit. In the procedure of corneal angiogenesis, the candidate biomaterials and polymer with putative pro- and anti-angiogenic factors were transplanted into the stromal pouch created by surgical approach. The penetration and ingrowth of nascent vessels into the avascular area is monitored by the time [133].
