**11. Conclusion**

*Bacillus thuringiensis* has undoubtedly been the most successful microbial agent for biological insect control of all time. However, different authors have warned of the generation of insect resistant to Bt-derived products, as well as genetically modified plants.

During the last two decades, new methods have been widely used on Bt to overcome resistance to insects, and it is expected that this advancing trend will be well continued in the future, including the search for new toxins and strains with increased toxic activity and the development of new biopesticides and technologies to maintain the success of this bioinsecticide which is a great challenge to overcome.

Nowadays there exist different lines of research that seek to use *Bt* in different applications, such as anticancer activity, promotion of plant growth; nematicide, antifungal and bactericidal activity among others. To achieve the implementation of these new features, it is necessary to know more about the biochemical and physiological pathways, as well as the mode of action of the new features. Such properties will undoubtedly lead to explore novel Bt strains with more potent insecticide activities or novel features which will enhance the implementation of these strains in other medical, agronomical, and industrial avenues. At the same time, technological development is necessary to allow new products to become a reality.
