**Author details**

Francesca Uberti1 \*, Lorenzo Secondini2 , Ian Stoppa1 , Mietta Catera2 and Claudio Molinari1

1 Physiology Laboratory, Department of Translational Medicine, UPO, Novara, Italy

2 Laborest Italia S.r.l., Gruppo Uriach, Assago Milan Italy

\*Address all correspondence to: francesca.uberti@med.uniupo.it

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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*Role of Alginates Combined with Natural Extracts to Prevent the Gastric Acid-Related Damage*

gastroesophageal reflux disease and analysis of genetic contributors. World Journal of Clinical Cases. 2018;**6**(8):176- 182. DOI: 10.12998/wjcc.v6.i8.176

[9] Sun Z, Liu H, Yang Z, Shao D, Zhang W, Ren Y, et al. Intestinal trefoil factor activates the PI3K/Akt signaling pathway to protect gastric mucosal epithelium from damage. International Journal of Oncology. 2014;**45**(3):1123- 1132. DOI: 10.3892/ijo.2014.2527

[10] Matsui H, Nagano Y, Shimokawa O, Kaneko T, Rai K, Udo J, et al. Gastric acid induces mitochondrial superoxide production and lipid peroxidation in gastric epithelial cells. Journal of Gastroenterology. 2011;**46**:1167-1176. DOI: 10.1007/s00535-011-0434-6

[11] Davidson G, Kritas S, Butler R. Stressed mucosa. Nestlé Nutrition Workshop Series. Paediatric Programme. 2007;**59**:133-142. DOI:

[12] Boeckxstaens GE. Neuroimmune interaction in the gut: From bench to bedside. Verhandelingen - Koninklijke Academie voor Geneeskunde van België.

[13] Iezzi A, Ferri C, Mezzetti A, Cipollone F. COX-2: Friend or foe? Current Pharmaceutical Design.

[14] Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. The Journal of Clinical Investigation. 2007;**117**:60-69.

[15] Murphy MP, Smith RA. Drug delivery to mitochondria: The key to mitochondrial medicine. Advanced Drug Delivery Reviews.

[16] Brand MD, Buckingham JA, Esteves TC, Green K, Lambert AJ, Miwa S,

10.1159/000098532

2006;**68**:329-335

2007;**13**:1715-1721

DOI: 10.1172/JCI30111

2000;**41**(2):235-250

*DOI: http://dx.doi.org/10.5772/intechopen.88135*

[1] Boland CR, Luciani MG, Gasche C, Goel A. Infection, inflammation, and gastrointestinal cancer. Gut.

[2] Hu XT, Ding C, Zhou N, Xu C. Quercetin protects gastric epithelial cell from oxidative damage in vitro and in vivo. European Journal of Pharmacology. 2015;**754**:115-124. DOI:

[3] Payment P, Hunter PR. Endemic and epidemic infectious intestinal disease and its relationship to drinking water. In: Fewtrell L, Bartram J, editors. Water Quality: Guidelines, Standards and Health. London: IWA Publishing; 2001.

[4] Uberti F, Bardelli C, Morsanuto V, Ghirlanda S, Molinari C. Role of vitamin D(3) combined to alginates in preventing acid and oxidative injury in cultured gastric epithelial cells. BMC Gastroenterology. 2016;**16**(1):127. DOI:

[5] Marseglia L, Manti S, D'Angelo G, Gitto E, Salpietro C, Centorrino A, et al. Gastroesophageal reflux and congenital

[6] Vandenplas Y, Hassall E. Mechanisms

gastroesophageal reflux disease. Journal of Pediatric Gastroenterology and Nutrition. 2002;**35**(2):119-136

[7] Galmiche JP, Clouse RE, Bálint A, Cook IJ, Kahrilas PJ, Paterson WG, et al. Functional esophageal disorders. Gastroenterology. 2006;**130**(5):1459- 1465. DOI: 10.1053/j.gastro.2005.08.060

[8] Argyrou A, Legaki E, Koutserimpas C, Gazouli M, Papaconstantinou I, Gkiokas G, et al. Risk factors for

gastrointestinal malformations. World Journal of Gastroenterology. 2015;**21**(28):8508-8515. DOI: 10.3748/

of gastroesophageal reflux and

wjg.v21.i28.8508

10.1186/s12876-016-0543-z

10.1016/j.ejphar.2015.02.007

2005;**54**:1321-1331

**References**

pp. 61-88

*Role of Alginates Combined with Natural Extracts to Prevent the Gastric Acid-Related Damage DOI: http://dx.doi.org/10.5772/intechopen.88135*
