**Abstract**

The human stomach is extremely vulnerable to various attacks able to cause erosion and mucosal epithelium damage which lead to gastrointestinal tract bleeding and/or ulcer perforations and finally worsen the original disease. A prolonged exposition to strong acidic environment causes coagulation necrosis resulting from the desiccating action of the acid on proteins in exposed tissues with inflammation and accumulation of intracellular radical oxygen species. Therapeutic strategies aim to treat both symptoms and epithelial damage with chemical or mechanical approaches. In this context, alginates seem to have great importance, especially if combined with other molecules known to have some properties on gastric epithelial cells, for example, vitamin D3, extract of prickly pear and olive leaves, and a tyndalized probiotic. This natural composition is able to exert a gastroprotective effect to maintain or restore the integrity of gastric epithelium through an antioxidant pathway, inhibiting apoptosis and activating survival kinases better than other pharmacological or natural active principles.

**Keywords:** alginates, vitamin D3, prickly pear, olive leaves, tyndalized probiotic
