*4.2.2 Vitamin E*

Vitamin E, C, and β-carotene are the main antioxidant vitamins for tissues against free radical damage. Vitamin E, a major lipid soluble antioxidant, functions as the most important membrane-bound antioxidant, neutralizing free radicals, and preventing oxidation of lipids within membranes [45]. Vitamin E is the free radical scavenger in the prevention of chronic diseases [46]. α-Tocopherol is the main form of vitamin E with antioxidant and immune functions. α-tocopherol has been revealed to be a more effective inhibitor of peroxynitrite-induced lipid peroxidation and inflammatory reactions [47]. *In vitro* tocotrienols have excellent antioxidant activity and have been proposed to restrain ROS more effectively than tocopherols [48].
