**4. Conclusions**

Summarizing the above, the results of these and other experiments demonstrate that natural antioxidants of polyphenolic structure have a significant corrective effect on major factors in the pathogenesis of obesity. Firstly, polyphenolic antioxidants promote lipid and carbohydrate metabolism, which is very important for directional therapy of obesity. In the other hand, these compounds prevent comorbid conditions of obesity, such as endothelial dysfunction and atherosclerosis, which greatly increases the risk of mortality. Also, polyphenolic antioxidants reverse insulin resistance and its after-effects linked with oxidative tissue damage. The main explanation of such protective effects of natural polyphenolic compounds is based on their powerful antioxidative properties, because the pathogenesis of noted disorders is usually amplified by exponential releasing reactive oxygen species and their products. Consequently, the pool of current experimental data points out that concentrates of polyphenolic compounds could be used in adjuvant therapy of obesity, diabetes, and similar conditions, complicated by metabolic disorders and free radical oxidation.
