*4.2.6.1 Application*

Studies showed that serum uric acid levels are highly predictive of mortality in patients with coronary artery disease, heart failure, or diabetes. In addition, high uric acid level is associated with deleterious effect on vascular function. Recently, it has been found that patients with high serum uric acid level had impaired flow-mediated dilation, which was normalized by therapy for 3 months with the xo inhibitor allopurinol [53].
