**1. Introduction**

According to clinical and epidemiological studies, obesity refers to diseases with high medical and social significance and has a pandemic rate of expansion. Obesity is a component of the multimorbid disease pathogenesis, in particular of metabolic syndrome (MS), type 2 diabetes mellitus (DT2), also it is a predictor of atherosclerosis and cardiovascular complications [1]. It is known that an imbalance of antioxidant-prooxidant factors (with a predominance of prooxidants) is associated with obesity development due to pathological changes in metabolic activity of the adipose tissue [2].

The reactive oxygen species (ROS) production is primarily caused by the lipid accumulation, so it results in NADPH-oxidase excessive expression with the simultaneous decrease in the activity of antioxidant enzymes and nonenzyme antioxidants. Carbohydrate metabolism disorders lead to the activation of glucose metabolism polyol pathway and to protein pathological glycosylation along with metabolic end products accumulation. Oxidative stress leads to adipokines production dysregulation, in particular, adiponectin, plasminogen activator inhibitor-1, interleukin-6, and monocyte chemotactic factor. It plays a leading role in the involvement of other metabolic pathways to the pathological process and main disease pathogenesis complications [3, 4].

Free radical upbuilding is a major event involved in vascular endothelium damaging as a trigger mechanism for the endothelial dysfunction (ED) and cardiovascular complications development related to obesity and MS. As is well known, just cardiovascular events determine high premature mortality rates of these patient categories. In addition, the pathological changes of the antioxidant-prooxidant balance leads to the low-density lipoproteins (LDL) oxidative modification, which are the leading link to the proatherogenic process essential for obesity and associated pathologies [5].

The metabolic disorders' pathogenetic aspects that appear under MS are mainly based on the free radical oxidation (FRO) processes activation. Concerning the above mentioned, the antioxidant use is promising treatment strategy for correction of pathological states that developed under the insulin resistance (IR) [6].

Common therapeutic pharmacological correction strategies for obesityassociated diseases include the synthetic drug use, which are powerful microsomal oxidation processes activators that, in turn, initiates the FRO intensification and increases the ROS production. Recently, there is an increasing interest to the development and research of natural origin substances that can be used at the complex obesity-associated pathologies treatment. Plant polyphenols with expressive antioxidant activity can potentially demonstrate a therapeutic effect under MS pathogenetic manifestations and related comorbidities, including ED [7]. The mentioned metabolic disorders are mediated by chronic subclinical inflammatory process, which is intermediated by the adipocytes production of various active molecules, which, as usual, are factors of high cardiometabolic risk. That is why the evaluation of usefulness of natural origin substances with antioxidant properties administration under the obesity treatment was the aim of our work.
