**2. Genesis of antibiotic resistance and its spread across geographical boundaries**

The World Health Organization (WHO) has emphasized the need for an integrated and coordinated global effort to control antibiotic resistance. In 2001, the World Health Organization Global Strategy for Containment of Antimicrobial Resistance has provided a framework of interventions to slow the emergence and reduce the spread of antimicrobial-resistant microorganisms across geographical boundaries and species [9]. For understanding the genesis and spread of antimicrobial resistance across species and increase in resistosome burden, the following sub-heads points the focus.
