**Abstract**

In the presented article, we cover the issues concerning physiology of secretion of pineal hormone melatonin and its role in the vital processes of a body. Focus is given to melatonin effect on the female reproductive system, its participation in the aging process, and formation of pathological menopause. The article also presents research data on the effectiveness of the melatonin drug when tackling climacteric syndrome. It is revealed that according to the available literature up to date there is no information about the standards of secretion of melatonin for women of different age groups, and the lack of secretion of melatonin can be judged by clinical manifestations and also when compared with groups of healthy women. The issues of the melatonin drug application at various complications of pregnancy and gynecological diseases remain unclear. Long-term intake of melatonin to treat pathologic menopause is still to be discussed.

**Keywords:** women, pineal gland, melatonin, 6-sulfatoxymelatonin
