**6. Therapy**

Osteosarcoma is typically treated with surgery and adjuvant chemotherapy that usually includes a combination of methotrexate, doxorubicin, and cisplatin [37]. Once the cancer has spread to the bones, it can rarely be cured, but often it can be treated to slow down its growth [38]. The therapeutic strategies for bone tumors should involve the following:


As discussed in the previous sections, various signaling pathway are involved in the proliferation and migration of tumor cells. Targeting these signaling pathways by use of different inhibitors could hamper the survival of tumor cells. However, it has

already been known that the sex hormones play a major role in tumor cell survival and metastases. Thus, hormone therapy for curing tumors would basically involve hormone deprivation approaches. These strategies might inhibit the action of hormones responsible to bone metastases, resulting in osteolytic or osteoblastic tumors.
