**Abstract**

The incidence of most cancers increases with age, especially from middle age onward, so today cancer can be considered an age-related disease. One of the keys to healthy and successful aging is reducing the advent of serious disabilities caused by diseases related to aging. One of the cornerstones of anti-aging is hormone replacement therapy to treat age-related diseases caused by sex hormone deficiency in women. However, there are many studies that question the relationship between hormone replacement therapies with cancer recurrence. Hormone replacement therapy (HRT) has the potential to affect both quality of life and survival in menopausal women. Although data in the literature is controversial, many clinicians remain reluctant to write HRT for gynecologic cancer patients due to fear of relapse but HRT does not appear to be associated with an increased risk of relapse in ovarian and endometrial cancer survivors, especially when used for a short period of time.

**Keywords:** endometrial cancer, gynecologic cancers, hormone replacement therapy, ovarian cancer, cervical cancer
