*2.3.1 Definition*

A pair of teeth is regarded as developing asymmetrically when the crown or root development of one of the teeth deviated from that of the antimeric tooth by at least one developmental stage. Ranta was one of the earliest authors to report on asymmetric tooth formation [18]. Studies have found that children with CLP had asymmetrical tooth formation that was 3–4 times more common than those of the control group [20, 21, 23]. The only study that did not report such a finding was by Borodkin et al. [21].
