**7. Conclusions**

Regorafenib and trifluridine/tipiracil have been authorized for the treatment of metastatic colorectal cancer, as the third or further therapy line. The patients are eligible for one of those treatments if they present with good performance status and adequate bone marrow, liver, and kidney function; hence, aside from clinical and molecular biomarker status, also those factors should be considered during patient qualification. While the toxicity of both anticancer agents is manageable, appropriate control of side effects requires clinical vigilance and good medication compliance. In some clinical situations, re-induction/re-challenge of previously given chemotherapy with oxaliplatin or irinotecan-based regimens and/or switching to mitomycin C plus capecitabine might be a reasonable option.

**87**

**Author details**

Aneta L. Zygulska

provided the original work is properly cited.

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

Department of Oncology, University Hospital in Krakow, Poland

\*Address all correspondence to: zygulska@poczta.onet.pl

*Further Therapeutic Options in Heavily Pretreated Colorectal Cancer Patients*

*DOI: http://dx.doi.org/10.5772/intechopen.85027*
