Pathogenesis of Colorectal Cancer

*Multidisciplinary Approach for Colorectal Cancer*

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**Chapter 3**

**Abstract**

A Genetic Perspective on

*and Wilson Vilela Medeiros-Filho*

the development an efficient therapy.

**1. Introduction**

**Keywords:** colorectal cancer, molecular biology, carcinogenesis

economic changes that are associated with cancer development [1].

diversity in types of colorectal cancer and genetic involvement.

Colorectal Cancer Progression

*Lenuce Ribeiro Aziz Ydy, Willian Ricardo Camarço-Silva* 

The colorectal cancer is one of most frequent neoplasia in adult population. Since was described the adenoma-carcinoma sequence for the first time in 1978, the elucidation of the molecular mechanisms involved in the pathogenesis of colorectal cancer became studied. The study of colorectal cancer has been one of the most important elements for understanding the mechanisms involved in the genesis of malignant neoplasms. Several genes, like DCC, APC, p53 were identified as participants of the adenoma-carcinoma. The annexin A1 protein (ANXA1) is related with some types of tumor and its study in colorectal cancer in scientific literature is been done, but discreetly yet. The increasing advancement in molecular biology research have contributes for understanding the carcinogenesis, with the possibility of detecting earlier pre-malignant lesions and a proper diagnosis, more over it allow

Colorectal cancer (CCR) is the third most common cancer in men, the second in women and the third most prevalent cause of mortality in the world. It was estimated more than 1.8 million new cases in 2018 according to American Institute for Cancer Research and Continuous Update project panel. It is linked to the transition nutrition to the western lifestyle, consuming processed meat, red meat and alcoholic drinks, greater body fatness and adult height increase the risk of the disease. The incidence of the disease continues to rise especially in low and middle income countries and it is considered one of the clearest markers for rapid societal and

Genetic knowledge is essential for understanding of carcinogenic colorectal cancer, and can develop strategies for prevention, diagnosis and treatment. A list of genes in which mutations are capable of interfering with both cancer creation and treatment, has grown a lot in recent years, helping to understand risks for cancer formation and identifying several promising therapeutic targets. Today focused on a best treatment, but research on colorectal cancer genetics began with a focus on diagnosis, much of our understanding of pathogenesis came from study of hereditary syndromes of colorectal diseases that advanced into cancer, showing a huge
