**6.2 Multivitamins-multivitamins were kept under the heading of "Supplementation" as the content under "Vitamins" in Section 3 is related to vitamins derived from whole foods and not supplements**

There is evidence that consuming multivitamin supplements might decrease the risk of CRC cancer [8]. However, the evidence is limited but generally consistent [8]. One RCT in men reported a nonsignificant inverse association for multivitamin supplementation compared to placebo. The analysis of highest versus lowest users of supplements showed a significant decreased risk of CRC. One published metaanalysis on CRC and colon cancer reported significant inverse associations. There is evidence of plausible mechanisms in humans [8].
